Percutaneous coronary intervention in asians- are there differences in clinical outcomeReport as inadecuate

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BMC Cardiovascular Disorders

, 11:22

First Online: 23 May 2011Received: 06 March 2011Accepted: 23 May 2011DOI: 10.1186-1471-2261-11-22

Cite this article as: Koh, A.S., Khin, L.W., Choi, L.M. et al. BMC Cardiovasc Disord 2011 11: 22. doi:10.1186-1471-2261-11-22


BackgroundEthnic differences in clinical outcome after percutaneous coronary intervention PCI have been reported. Data within different Asian subpopulations is scarce. We aim to explore the differences in clinical profile and outcome between Chinese, Malay and Indian Asian patients who undergo PCI for coronary artery disease CAD.

MethodsA prospective registry of consecutive patients undergoing PCI from January 2002 to December 2007 at a tertiary care center was analyzed. Primary endpoint was major adverse cardiovascular events MACE of myocardial infarction MI, repeat revascularization and all-cause death at six months.

Results7889 patients underwent PCI; 7544 96% patients completed follow-up and were included in the analysis 79% males with mean age of 59 years ± 11. There were 5130 68% Chinese, 1056 14% Malays and 1001 13.3% Indian patients. The remaining 357 4.7% patients from other minority ethnic groups were excluded from the analysis. The primary end-point occurred in 684 9.1% patients at six months. Indians had the highest rates of six month MACE compared to Chinese and Malays Indians 12% vs. Chinese 8.2% vs. Malays 10.7%; OR 1.55 95%CI 1.24-1.93, p < 0.001. This was contributed by increased rates of MI Indians 1.9% vs. Chinese 0.9% vs. Malays 1.3%; OR 4.49 95%CI 1.91-10.56 p = 0.001, repeat revascularization Indians 6.5% vs. Chinese 4.1% vs. Malays 5.1%; OR 1.64 95%CI 1.22-2.21 p = 0.0012 and death Indians 11.4% vs. Chinese 7.6% vs. Malays 9.9%; OR 1.65 95%CI 1.23-2.20 p = 0.001 amongst Indian patients.

ConclusionThese data indicate that ethnic variations in clinical outcome exist following PCI. In particular, Indian patients have higher six month event rates compared to Chinese and Malays. Future studies are warranted to elucidate the underlying mechanisms behind these variations.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2261-11-22 contains supplementary material, which is available to authorized users.

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Author: Angela S Koh - Lay W Khin - Lok M Choi - Ling L Sim - Terrance S Chua - Tian H Koh - Jack W Tan - Stanley Chia


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