Effects of nanoparticle zinc oxide on spatial cognition and synaptic plasticity in mice with depressive-like behaviorsReport as inadecuate

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Journal of Biomedical Science

, 19:14

First Online: 03 February 2012Received: 19 October 2011Accepted: 03 February 2012DOI: 10.1186-1423-0127-19-14

Cite this article as: Xie, Y., Wang, Y., Zhang, T. et al. J Biomed Sci 2012 19: 14. doi:10.1186-1423-0127-19-14


BackgroundNanomaterials, as a new kind of materials, have been greatly applied in different fields due to their special properties. With the industrialization of nanostructured materials and increasing public exposure, the biosafety and potential influences on central nervous system CNS have received more attention. Nanosized zinc oxide nanoZnO was suggested to up-regulate neuronal excitability and to induce glutamate release in vitro. Therefore, we hypothesized nanoparticles of nanoZnO may lead to changes in balance of neurotransmitter or neuronal excitability of CNS. This study was to investigate if there were effects of nanoZnO on animal model of depression.

MethodsMale Swiss mice were given lipopolysaccharides LPS, 100 μg-kg, 100 μg-ml, every other day, 8 times, i.p. from weaning to induce depressive-like behaviors. NanoZnO 5.6 mg-kg, 5.6 mg-ml, every other day, 8 times, i.p. was given as the interaction. The mouse model was characterized using the methods of open field test, tail suspension test and forced swim test. Furthermore, the spatial memory was evaluated using Morris water maze MWM and the synaptic plasticity was assessed by measuring the long-term potentiation LTP in the perforant pathway PP to dentate gyrus DG in vivo.

ResultsResults indicated that model mice showed disrupted spatial memory and LTP after LPS injections and the behavioral and electrophysiological improvements after nanoZnO treatment.

ConclusionData suggested that nanoZnO may play some roles in CNS of mental disorders, which could provide some useful direction on the new drug exploring and clinical researches.

KeywordsMorris water maze long-term potentiation depression hippocampus nanoparticles zinc oxide nanoZnO AbbreviationsCNScentral nervous system

DGdentate gyrus

fEPSPsfield excitatory postsynaptic potentials

FSTforced swim test

FHCbipolar stimulating electrode

GABAγ-amino butyric acid


HELCHigh Performance Liquid Chromatography

HFShigh frequency stimulus



LTPlong-term potentiation

MWMMorris water maze

nanoZnOnanosized zinc oxide

OFTopen field test

PPperforant pathway

TSTtail suspension test

ZnOzinc oxide

Electronic supplementary materialThe online version of this article doi:10.1186-1423-0127-19-14 contains supplementary material, which is available to authorized users.

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Author: Yongling Xie - Yiyi Wang - Tao Zhang - Guogang Ren - Zhuo Yang

Source: https://link.springer.com/

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