Genetic polymorphisms in MMP 2, 9 and 3genes modify lung cancer risk and survivalReport as inadecuate

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BMC Cancer

, 12:121

First Online: 28 March 2012Received: 29 November 2011Accepted: 28 March 2012DOI: 10.1186-1471-2407-12-121

Cite this article as: González-Arriaga, P., Pascual, T., García-Alvarez, A. et al. BMC Cancer 2012 12: 121. doi:10.1186-1471-2407-12-121


BackgroundMatrix metalloproteases MMPs are proteolytic enzymes that contribute to all stages of tumour progression, including the later stages of invasion and metastasis. Genetic variants in the MMP genes may influence the biological function of these enzymes and change their role in carcinogenesis and progression. We have investigated the association between the -735 C-T, the -1171 5A-6A, and the -1562 C-T polymorphisms in the MMP2, MMP3 and MMP9 genes, respectively, and the risk and survival of lung cancer.

MethodsThe case-control study includes 879 lung cancer patients and 803 controls from a Caucasian population in Spain CAPUA study. Genotypes were determined by PCR-RFLP. Odds ratios OR and 95% confidence intervals CI were calculated using unconditional logistic regression. The Kaplan-Meier method, long-rank test and Cox-s were used for the survival analysis.

ResultsThe MMP9 -1562 T-T genotype was associated with a statistically significant decreased risk of developing lung cancer OR = 0.23; 95% CI: 0.06-0.85, whereas no association was found for the MMP2 -735 C-T and MMP3 -1171 5A-6A polymorphisms. The MMP2 -735 T-T genotype was statistically significantly associated with a decreased survival in non-small cell lung cancer NSCLC patients, identified as an independent prognosis factor of survival hazard ratio HR = 1.79; 95% CI: 1.00-3.20. In contrast, no association was found between the MMP3 -1171 5A-6A and the MMP9 -1562 C-T polymorphisms and survival.

ConclusionsThese findings support the hypothesis that the MMP9 -1562 C-T polymorphism is associated with a protective effect against the development of lung cancer and suggest that the MMP2 -735 C-T polymorphism modify the length of survival in NSCLC patients.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-12-121 contains supplementary material, which is available to authorized users.

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Author: Patricia González-Arriaga - Teresa Pascual - Arturo García-Alvarez - Ana Fernández-Somoano - M Felicitas López-Cima - Ad


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