Seroprevalence of hepatitis B e antigen HBe antigen and B core antibodies IgG anti-HBcore and IgM anti-HBcore among hepatitis B surface antigen positive blood donors at a Tertiary Centre in NigeriaReportar como inadecuado




Seroprevalence of hepatitis B e antigen HBe antigen and B core antibodies IgG anti-HBcore and IgM anti-HBcore among hepatitis B surface antigen positive blood donors at a Tertiary Centre in Nigeria - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Research Notes

, 5:167

First Online: 28 March 2012Received: 19 October 2011Accepted: 28 March 2012DOI: 10.1186-1756-0500-5-167

Cite this article as: Akinbami, A.A., Oshinaike, O.O., Dosunmu, O.A. et al. BMC Res Notes 2012 5: 167. doi:10.1186-1756-0500-5-167

Abstract

BackgroundHepatitis B virus HBV is a common cause of liver disease throughout the world. HBV is transmitted through blood and other body fluids, including semen and saliva. Chronic replication of HBV virons is characterized by persistence circulation of HBsAg, HBeAg and HBV DNA; usually with anti-HBc and occasionally with anti-HBs. Aim: To determine the prevalence of HBeAg, IgG anti-HBcore and IgM anti-HBcore amongst HBsAg positive blood donors. These parameters are reflective of transmissibility and active hepatitis B infection. A cross sectional study was carried out at the blood donor clinics of Lagos State University Teaching Hospital Ikeja and Lagos University Teaching Hospital Idiaraba. A total of 267 donors were recruited to determine HBe antigen, IgG and IgM anti-HBcore antibodies amongst hepatitis BsAg positive donors. Five milliliters of blood was collected from those who tested positive to HBsAg screen during donation. The sera were subjected to enzyme linked immunosorbent assay ELISA. Pearson chi-squared test was used for the analytical assessment.

FindingsA total number of 267 HBsAg positive blood donors were studied. A seroprevalence of 8.2% 22 of 267 HBeAg was obtained, 4 of 267 1.5% were indeterminate while 241 90.3% tested negative. Only 27 out of 267 donors 10.1% tested positive to IgM anti-HBcore, 23487.6% tested negative, while 62.2% were indeterminate. A higher percentage of 60.7% 162 of 267 tested positive to IgG anti-HBcore, while 39.3% 105 of 267 tested negative.

ConclusionThere is a low seroprevalence rate of HBeAg-positive chronic hepatitis and relatively high IgG anti-HBcore and IgM anti-HBcore rates in South West Nigeria.

KeywordsSeroprevalence HBeAg HBsAg IgG anti-HBc IgM anti-HBc Blood donors  Download fulltext PDF



Autor: Akinsegun A Akinbami - Olajumoke O Oshinaike - Owolabi A Dosunmu - Titilope A Adeyemo - Adewumi Adediran - Sulaiman Akan

Fuente: https://link.springer.com/







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