A randomized controlled trial on the effectiveness of strength training on clinical and muscle cellular outcomes in patients with prostate cancer during androgen deprivation therapy: rationale and designReportar como inadecuado




A randomized controlled trial on the effectiveness of strength training on clinical and muscle cellular outcomes in patients with prostate cancer during androgen deprivation therapy: rationale and design - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Cancer

, 12:123

First Online: 29 March 2012Received: 29 February 2012Accepted: 29 March 2012DOI: 10.1186-1471-2407-12-123

Cite this article as: Thorsen, L., Nilsen, T.S., Raastad, T. et al. BMC Cancer 2012 12: 123. doi:10.1186-1471-2407-12-123

Abstract

BackgroundStudies indicate that strength training has beneficial effects on clinical health outcomes in prostate cancer patients during androgen deprivation therapy. However, randomized controlled trials are needed to scientifically determine the effectiveness of strength training on the muscle cell level. Furthermore, close examination of the feasibility of a high-load strength training program is warranted. The Physical Exercise and Prostate Cancer PEPC trial is designed to determine the effectiveness of strength training on clinical and muscle cellular outcomes in non-metastatic prostate cancer patients after high-dose radiotherapy and during ongoing androgen deprivation therapy.

Methods-designPatients receiving androgen deprivation therapy for 9-36 months combined with external high-dose radiotherapy for locally advanced prostate cancer are randomized to an exercise intervention group that receives a 16 week high-load strength training program or a control group that is encouraged to maintain their habitual activity level. In both arms, androgen deprivation therapy is continued until the end of the intervention period.

Clinical outcomes are body composition lean body mass, bone mineral density and fat mass measured by Dual-energy X-ray Absorptiometry, serological outcomes, physical functioning muscle strength and cardio-respiratory fitness assessed with physical tests and psycho-social functioning mental health, fatigue and health-related quality of life assessed by questionnaires. Muscle cellular outcomes are a muscle fiber size b regulators of muscle fiber size number of myonuclei per muscle fiber, number of satellite cells per muscle fiber, number of satellite cells and myonuclei positive for androgen receptors and proteins involved in muscle protein degradation and muscle hypertrophy and c regulators of muscle fiber function such as proteins involved in cellular stress and mitochondrial function. Muscle cellular outcomes are measured on muscle cross sections and muscle homogenate from muscle biopsies obtained from muscle vastus lateralis.

DiscussionThe findings from the PEPC trial will provide new knowledge on the effects of high-load strength training on clinical and muscle cellular outcomes in prostate cancer patients during androgen deprivation therapy.

Trial registrationClinicalTrials.gov: NCT00658229

KeywordsStrength training Prostate cancer Androgen deprivation therapy Clinical and muscle cellular outcomes Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-12-123 contains supplementary material, which is available to authorized users.

Lene Thorsen, Tormod S Nilsen contributed equally to this work.

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Autor: Lene Thorsen - Tormod S Nilsen - Truls Raastad - Kerry S Courneya - Eva Skovlund - Sophie D Fosså

Fuente: https://link.springer.com/







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