Mortality in cancer patients with a history of cutaneous squamous cell carcinoma - a nationwide population-based cohort studyReportar como inadecuado




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BMC Cancer

, 12:126

First Online: 29 March 2012Received: 10 November 2011Accepted: 29 March 2012DOI: 10.1186-1471-2407-12-126

Cite this article as: Johannesdottir, S.A., Lash, T.L., Jensen, A.Ø. et al. BMC Cancer 2012 12: 126. doi:10.1186-1471-2407-12-126

Abstract

BackgroundCutaneous squamous cell carcinoma SCC is associated with underlying immunosuppression, so it may be a prognostic marker in patients with subsequent cancer. We therefore conducted a nationwide population-based Danish cohort study to evaluate whether a history of cutaneuos SCC has prognostic impact in patients with one of the following index cancers: non-Hodgkin-s lymphoma NHL, or cancer of the lung, colon, rectum, breast, or prostate.

MethodsWe used Danish medical databases, which cover the entire Danish population of 5.6 million inhabitants and linked them using the unique personal identification number assigned to all Danish residents. From 1982 through 2003, we identified 745 index cancer patients with and 79,143 without previous cutaneous SCC. Using Cox proportional hazards regression, we calculated adjusted mortality rate ratios MRRs with 95% confidence intervals CIs.

ResultsOverall, previous SCC was associated with an increased mortality of cancer MRR 1.13, 95% CI: 1.04-1.23. When examining index cancers separately, increased MRRs were found for cancer of the lung MRR 1.23, 95% CI: 1.05-1.43, colon MRR 1.13, 95% CI: 0.92-1.40, rectum MRR 1.29, 95% CI: 1.00-1.67, breast MRR 1.09, 95% CI: 0.82-1.43, and NHL MRR 1.09, 95% CI: 0.81-1.47, but not for prostate cancer MRR 0.99, 95% CI: 0.83-1.18.

ConclusionsOur results suggest that previous cutaneous SCC is associated with poor prognosis of some cancers. This finding stresses the importance of adherence to the existing recommendations of screening, diagnosis, and treatment of cancer in patients with a history of SCC.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-12-126 contains supplementary material, which is available to authorized users.

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Autor: Sigrun Alba Johannesdottir - Timothy L Lash - Annette Østergaard Jensen - Dóra Körmendiné Farkas - Anne Braae Olesen

Fuente: https://link.springer.com/







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