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BMC Research Notes

, 5:169

First Online: 31 March 2012Received: 18 August 2011Accepted: 31 March 2012DOI: 10.1186-1756-0500-5-169

Cite this article as: Akiibinu, M.O., Ogundahunsi, O.A. & Ogunyemi, E.O. BMC Res Notes 2012 5: 169. doi:10.1186-1756-0500-5-169


BackgroundThe relationship of oxidative stress to thyroid hormones has not been studied in the schizophrenics. The present study determined the status and interrelationship of plasma markers of oxidative stress, nitric oxide and thyroid hormones in thirty 17 males and 13 females newly diagnosed patients with acute schizophrenia before initiation of chemotherapy. Twenty five 13 males and 12 females mentally healthy individuals served as controls. Patients and controls with history of hard drugs including alcohol and cigarette, pre-diagnosis medications e.g. antiparkinsonian-antipsychotic drugs, chronic infections, liver disease and diabetes mellitus were excluded from the study. Plasma levels of total antioxidant potential TAP, total plasma peroxides TPP, nitric oxide NO, malondialdehyde MDA, thyroxine T4, tri-iodothyronine T3 and thyroid stimulating hormone TSH were determined in all participants using spectrophotometric and enzyme linked immunosorbent assay ELISA methods respectively. Oxidative stress index OSI was calculated as the percent ratio of total plasma peroxides and total antioxidant potential.

FindingsSignificantly higher plasma levels of MDA p < 0.01, TPP p < 0.01, OSI p < 0.01, T3 p < 0.01 and T4 p < 0.05 were observed in schizophrenics when compared with the controls. The mean levels of TAP, NO and TSH were significantly lower in schizophrenics p < 0.01 when compared with the controls. The result shows that T3 values correlate significantly with MDA p < 0.05 and TPP p < 0.01 in schizophrenics.

ConclusionsHigher level of TPP may enhance thyroid hormogenesis in schizophrenics. Adjuvant antioxidant therapy may be a novel approach in the treatment of schizophrenic patients.

KeywordsOxidative stress Thyroid hormones Schizophrenia  Download fulltext PDF

Autor: Moses O Akiibinu - Omobola A Ogundahunsi - Ebenezer O Ogunyemi


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