Glutathione S-transferase Pi expression predicts response to adjuvant chemotherapy for stage C colon cancer: a matched historical control studyReportar como inadecuado




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BMC Cancer

, 12:196

First Online: 28 May 2012Received: 24 December 2011Accepted: 11 May 2012DOI: 10.1186-1471-2407-12-196

Cite this article as: Jankova, L., Robertson, G., Chan, C. et al. BMC Cancer 2012 12: 196. doi:10.1186-1471-2407-12-196

Abstract

BackgroundThis study examined the association between overall survival and Glutathione S-transferase Pi GST Pi expression and genetic polymorphism in stage C colon cancer patients after resection alone versus resection plus 5-fluourouracil-based adjuvant chemotherapy.

MethodsPatients were drawn from a hospital registry of colorectal cancer resections. Those receiving chemotherapy after it was introduced in 1992 were compared with an age and sex matched control group from the preceding period. GST Pi expression was assessed by immunohistochemistry. Overall survival was analysed by the Kaplan-Meier method and Cox regression.

ResultsFrom an initial 104 patients treated with chemotherapy and 104 matched controls, 26 were excluded because of non-informative immunohistochemistry, leaving 95 in the treated group and 87 controls. Survival did not differ significantly among patients with low GST Pi who did or did not receive chemotherapy and those with high GST Pi who received chemotherapy lowest pair-wise p = 0.11 whereas patients with high GST Pi who did not receive chemotherapy experienced markedly poorer survival than any of the other three groups all pair-wise p <0.01. This result was unaffected by GST Pi genotype.

ConclusionStage C colon cancer patients with low GST Pi did not benefit from 5-fluourouracil-based adjuvant chemotherapy whereas those with high GST Pi did.

KeywordsColon cancer GST Pi Adjuvant chemotherapy Survival AbbreviationsGST PiGlutathione S-transferase Pi

5FU5-fluourouracil

GSHThe nucleophilic thiol group of reduced glutathione.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-12-196 contains supplementary material, which is available to authorized users.

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Autor: Lucy Jankova - Graham Robertson - Charles Chan - King L Tan - Maija Kohonen-Corish - Caroline L-S Fung - Candice Clarke -

Fuente: https://link.springer.com/







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