Genetic predisposition for sudden cardiac death in myocardial ischaemia: the Arrhythmia Genetics in the NEtherlandS studyReportar como inadecuado




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Netherlands Heart Journal

, Volume 19, Issue 2, pp 96–100

First Online: 28 January 2011DOI: 10.1007-s12471-010-0070-4

Cite this article as: Marsman, R.F.J., Wilde, A.A.M. & Bezzina, C.R. Neth Heart J 2011 19: 96. doi:10.1007-s12471-010-0070-4

Abstract

Sudden cardiac death from ventricular fibrillation during myocardial infarction is a leading cause of total and cardiovascular mortality. This multifactorial, complex condition clusters in families, suggesting a substantial genetic cause. We carried out a genomewide association study GWAS for sudden cardiac death, in the AGNES Arrhythmia Genetics in the Netherlands population, consisting of patients with cases and without controls ventricular fibrillation during a first ST-elevation myocardial infarction. The most significant association was found at chromosome 21q21 rs2824292; odds ratio = 1.78, 95% CI 1.47–2.13, P = 3.3 × 10, 98 kb proximal of the CXADR gene, encoding the Coxsackie and adenovirus receptor. This locus has not previously been implicated in arrhythmia susceptibility. Further research on the mechanism of this locus will ultimately provide novel insight into arrhythmia mechanisms in this condition.

KeywordsSudden cardiac death Ventricular fibrillation Genomewide association study Single nucleotide polymorphism  Download fulltext PDF



Autor: R. F. J. Marsman - A. A. M. Wilde - C. R. Bezzina

Fuente: https://link.springer.com/







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