Unsuspected pulmonary alveolar proteinosis in a patient with acquired immunodeficiency syndrome: a case reportReport as inadecuate

Unsuspected pulmonary alveolar proteinosis in a patient with acquired immunodeficiency syndrome: a case report - Download this document for free, or read online. Document in PDF available to download.

Journal of Medical Case Reports

, 5:46

First Online: 01 February 2011Received: 20 February 2010Accepted: 01 February 2011DOI: 10.1186-1752-1947-5-46

Cite this article as: Tejwani, D., DeLaCruz, A.E., Niazi, M. et al. J Med Case Reports 2011 5: 46. doi:10.1186-1752-1947-5-46


IntroductionDiffuse lung infiltrates are a common finding in patients with acquired immunodeficiency syndrome and causes range from infectious processes to malignancies or interstitial lung diseases. Pulmonary alveolar proteinosis is a rare pulmonary disorder rarely reported in patients infected with human immunodeficiency virus. Secondary pulmonary alveolar proteinosis is associated with conditions involving functional impairment or reduced numbers of alveolar macrophages. It can be caused by hematologic malignancies, inhalation of toxic dust, fumes or gases, infectious or pharmacologic immunosuppression, or lysinuric protein intolerance.

Case presentationA 42-year-old African American man infected with human immunodeficiency virus was admitted with chronic respiratory symptoms and diffuse pulmonary infiltrates. Chest computed tomography revealed bilateral spontaneous pneumothoraces, for which he required bilateral chest tubes. Initial laboratory investigations did not reveal any contributory conditions. Histological examination of a lung biopsy taken during video-assisted thoracoscopy showed pulmonary alveolar proteinosis concurrent with cytomegalovirus pneumonitis. After ganciclovir treatment, our patient showed radiologic and clinical improvement.

ConclusionThe differential diagnosis for patients with immunosuppression and lung infiltrates requires extensive investigations. As pulmonary alveolar proteinosis is rare, the diagnosis can be easily missed. Our case highlights the importance of invasive investigations and histology in the management of patients infected with human immunodeficiency virus and pulmonary disease who do not respond to empiric therapy.

Electronic supplementary materialThe online version of this article doi:10.1186-1752-1947-5-46 contains supplementary material, which is available to authorized users.

Download fulltext PDF

Author: Dimple Tejwani - Angel E DeLaCruz - Masooma Niazi - Gilda Diaz-Fuentes

Source: https://link.springer.com/


Related documents