Association of iron overload based quantitative T2* MRI technique and carotid intima-media thickness in patients with beta-thalassemia: A cross-sectional studyReportar como inadecuado




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BMC Cardiovascular Disorders

, 10:62

First Online: 31 December 2010Received: 14 July 2010Accepted: 31 December 2010DOI: 10.1186-1471-2261-10-62

Cite this article as: Akhlaghpoor, S., Hoseini, M. & Jafarisepehr, A. BMC Cardiovasc Disord 2010 10: 62. doi:10.1186-1471-2261-10-62

Abstract

BackgroundBody iron status has been implicated in atherosclerotic cardiovascular disease. The main hypothesis is that high iron status is associated with increased risk of atherosclerosis. We investigated the potential role of iron as an additional risk factor promoting atherosclerosis among beta-thalassemic patients.

MethodsIn this cross-sectional study, the liver iron load was assessed by quantitative T2* MRI technique and intima-media thickness IMT of the common carotid artery by high-resolution ultrasound among 119 patients 62 male, 57 female with beta-thalassemia major and intermediate whose age ranged from 10 to 50 years with a mean of 25.6 years. The patients were divided into three groups according to the severity of iron loading, obtained by T2*MRI technique: group I normal, group II mild and group III moderate and severe iron load.

For elimination of the effect of age on carotid IMT values, the patients also were divided into four age groups 10-19 y, 20-29 y, 30-39 y and 40-50 y. Mean carotid IMT based on the severity of iron loading were compared at different age groups, using one way ANOVA analysis for assessing the effect of iron loading on carotid IMT. Pearson-s coefficient of correlation were used to assess the degree of correlation between studied variables liver T2*, IMT, age.

ResultsThere were significant differences in mean carotid IMT based on the severity of iron loading at different age groups, with P = 0.003 at 20-29 y, P = 0.006 at 30-39 y and p = 0.037 at 40-50 y. Age p = 0.001 and liver T2*p = 0.003 had significant correlation with mean carotid IMT independently.

At the age group of 10-19 years, there were not significant differences in mean carotid IMT based on the liver iron loading p = 0.661.

No significant differences also are seen in mean carotid IMT between male and female p = 0.41.

ConclusionsThis study identified a relationship between body iron status and carotid IMT. This relationship support to the hypothesis of a link between body iron load and atherosclerosis.

AbbreviationsIMTintima-media thickness

CHDcoronary heart disease

LICliver iron concentration

LDLLow density lipoprotein

T2* MRIT2-star Magnetic resonance imaging

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2261-10-62 contains supplementary material, which is available to authorized users.

Morteza Hoseini and Amirhosein Jafarisepehr contributed equally to this work.

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Autor: Shahram Akhlaghpoor - Morteza Hoseini - Amirhosein Jafarisepehr

Fuente: https://link.springer.com/







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