Effectiveness of rifaximin and fluoroquinolones in preventing travelers’ diarrhea TD: a systematic review and meta-analysisReportar como inadecuado

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Systematic Reviews

, 1:39

First Online: 28 August 2012Received: 31 May 2012Accepted: 13 August 2012DOI: 10.1186-2046-4053-1-39

Cite this article as: Alajbegovic, S., Sanders, J.W., Atherly, D.E. et al. Syst Rev 2012 1: 39. doi:10.1186-2046-4053-1-39


BackgroundRecent developments related to a safe and effective nonabsorbable antibiotic, rifaximin, and identification of postinfectious irritable bowel syndrome as a frequent sequela call for a need to reconsider the value of primary prevention of traveler’s diarrhea TD with antibiotics.

MethodsRandomized, placebo-controlled, double-blind studies evaluating the effectiveness and safety of rifaximin or a fluoroquinolone chemoprophylaxis against TD were pooled using a random effects model and assessed for heterogeneity.

ResultsThe nine studies four rifaximin and five fluoroquinolone included resulted in pooled relative risk estimates of 0.33 95% CI = 0.24–0.45, I = 3.1% and 0.12 95% CI = 0.07–0.20, I =0.0%, respectively. Similar rates of treatment emergent adverse events were found between antibiotic and placebo groups.

ConclusionsThis meta-analysis supports the effectiveness of antibiotics in preventing TD. However, further studies that include prevention of secondary chronic health outcomes among travelers to different geographic regions, and a formal risk-benefit analysis for antibiotic chemoprophylaxis, are needed.

KeywordsTravelers’ diarrhea Chemoprophylaxis Systematic review Meta-analysis Rifaximin Fluoroquinolone Electronic supplementary materialThe online version of this article doi:10.1186-2046-4053-1-39 contains supplementary material, which is available to authorized users.

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Autor: Sanjin Alajbegovic - John W Sanders - Deborah E Atherly - Mark S Riddle

Fuente: https://link.springer.com/

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