Left ventricular filling pressure assessed by exercise TDI was correlated with early HFNEF in patients with non-obstructive hypertrophic cardiomyopathyReportar como inadecuado




Left ventricular filling pressure assessed by exercise TDI was correlated with early HFNEF in patients with non-obstructive hypertrophic cardiomyopathy - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Cardiovascular Disorders

, 14:194

Non-coronary artery cardiac disease

Abstract

BackgroundHypertrophic cardiomyopathy HCM patients are more susceptible to suffer from heart failure with normal ejection fraction HFNEF. Therefore, it is critical to evaluate the relationship between left ventricular filling pressure LVFP and HFNEF, even if a large proportion of HCM patients have normal LVFP at rest. The objective was to assess the correlation between exercise tissue Doppler imaging TDI and early HFNEF in HCM patients by treadmill exercise echocardiography combined with cardiopulmonary exercise test CPET.

MethodTwenty-seven non-obstructive HCM patients and 31 age- and gender-matched healthy volunteers were enrolled in this study. All subjects underwent treadmill exercise echocardiography combined with CPET. N-terminal pro-brain natriuretic peptide NT-proBNP levels were analyzed before and after exercise.

ResultFive HCM patients had normal LVFP at rest and increased after exercise. For this subgroup, the relationship between minute ventilation and carbon dioxide production VE-VCO2 slope and NT-proBNP levels were higher compared with controls and the subgroup with normal resting and stress LVFP, but was similar to the subgroup with elevated LVFP both at rest and after exercise.

ConclusionElevated LVFP after exercise suggested the occurrence of early HFNEF in patients with non-obstructive HCM.

KeywordsTissue Doppler imaging Heart failure with normal ejection fraction Non-obstructive hypertrophic cardiomyopathy Cardiopulmonary exercise testing N-terminal pro-brain natriuretic peptide Electronic supplementary materialThe online version of this article doi:10.1186-1471-2261-14-194 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Autor: Guodong Ma - Ming Xu - Wei Gao - Zhaoping Li - Weihong Li - Baoxia Chen - Jieli Feng - Hongyan Wang - Wenying Ma - Hui C

Fuente: https://link.springer.com/







Documentos relacionados