Tissue laser biostimulation promotes post-extraction neoangiogenesis in HIV-infected patientsReport as inadecuate

Tissue laser biostimulation promotes post-extraction neoangiogenesis in HIV-infected patients - Download this document for free, or read online. Document in PDF available to download.

Lasers in Medical Science

, Volume 30, Issue 2, pp 701–706

First Online: 06 August 2013Received: 23 April 2013Accepted: 22 July 2013DOI: 10.1007-s10103-013-1411-5

Cite this article as: Halon, A., Donizy, P., Dziegala, M. et al. Lasers Med Sci 2015 30: 701. doi:10.1007-s10103-013-1411-5


The aim of the study was to assess the rate of neoangiogenesis in extraction wound healing following exposure to biostimulating laser therapy and to analyze the correlation between parameters of neoangiogenesis as reflected by the number and surface area of newly formed blood vessels and clinical parameters such as gender, position of a tooth in the oral cavity, and CD4 lymphocyte count. Twenty-seven patients with confirmed HIV infection were enrolled in the study 6 women, 21 men. Eighty-nine teeth were extracted; 45 sockets were exposed to 6 J laser radiation laser parameters were set as follows: wavelength, 820 nm; output, 200 mW; dose, 6 J-cm; spot size, 38 mm; continuous radiation for five consecutive days following tooth extraction, and the remaining extraction wounds were left to heal spontaneously without laser irradiation. Antigen CD34 was assessed by immunohistochemistry as a marker of angiogenesis, and its expression was examined by computer-assisted histomorphometric image analysis. As a result, we report that biostimulating laser therapy in HIV-infected patients of varying degrees of immunodeficiency greatly accelerated post-extraction neoangiogenesis, regardless of the patient-s gender, tooth position, number of roots, or number of CD4 lymphocytes in the blood. Application of low-level laser therapy for the treatment of tooth extraction wounds in HIV+ patients greatly enhanced the formation of new blood vessels, which in turn promoted wound healing.

KeywordsHuman immunodeficiency Low-level laser therapies Biostimulation Tooth extraction  Download fulltext PDF

Author: Agnieszka Halon - Piotr Donizy - Mateusz Dziegala - Rafal Dobrakowski - Krzysztof Simon

Source: https://link.springer.com/

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