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BMC Cancer

, 10:382

Genetics, genomics and epigenetics


BackgroundEndometrial cancer is the most common gynaecological malignancy in women of developed countries. Many risk factors implicated in endometrial cancer trigger inflammatory events; therefore, alterations in immune response may predispose an individual to disease. Toll-like receptors TLRs and nucleosome-binding oligomerization domain NOD genes are integral to the recognition of pathogens and are highly polymorphic. For these reasons, the aim of the study was to assess the frequency of polymorphic variants in TLR and NOD genes in an Australian endometrial cancer population.

MethodsTen polymorphisms were genotyped in 191 endometrial cancer cases and 291 controls using real-time PCR: NOD1 rs2075822, rs2907749, rs2907748, NOD2 rs5743260, rs2066844, rs2066845, TLR2 rs5743708, TLR4 rs4986790 and TLR9 rs5743836, rs187084.

ResultsHaplotype analysis revealed that the combination of the variant alleles of the two TLR9 polymorphisms, rs5743836 and rs187084, were protective for endometrial cancer risk: OR 0.11, 95% CI 0.03-0.44, p = 0.002. This result remained highly significant after adjustment for endometrial cancer risk factors and Bonferroni correction for multiple testing. There were no other associations observed for the other polymorphisms in TLR2, TLR4, NOD1 and NOD2.

ConclusionsThe variant -C- allele of rs5743836 causes greater TLR9 transcriptional activity compared to the -T- allele, therefore, higher TLR9 activity may be related to efficient removal of microbial pathogens within the endometrium. Clearly, the association of these TLR9 polymorphisms and endometrial cancer risk must be further examined in an independent population. The results point towards the importance of examining immune response in endometrial tumourigenesis to understand new pathways that may be implicated in disease.

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Autor: Katie A Ashton - Anthony Proietto - Geoffrey Otton - Ian Symonds - Mark McEvoy - John Attia - Rodney J Scott


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