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Cellular and Molecular Life Sciences

, Volume 70, Issue 6, pp 1055–1066

First Online: 25 August 2012Received: 28 June 2012Revised: 24 July 2012Accepted: 26 July 2012DOI: 10.1007-s00018-012-1110-6

Cite this article as: Bazigou, E. & Makinen, T. Cell. Mol. Life Sci. 2013 70: 1055. doi:10.1007-s00018-012-1110-6


The efficient transport of blood and lymph relies on competent intraluminal valves that ensure unidirectional fluid flow through the vessels. In the lymphatic vessels, lack of luminal valves causes reflux of lymph and can lead to lymphedema, while dysfunction of venous valves is associated with venous hypertension, varicose veins, and thrombosis that can lead to edema and ulcerations. Despite their clinical importance, the mechanisms that regulate valve formation are poorly understood and have only recently begun to be characterized. Here, we discuss new findings regarding the development of venous and lymphatic valves that indicate the involvement of common molecular mechanisms in regulating valve formation in different vascular beds.

KeywordsValve Lymphatic vessel Vein Endothelium Morphogenesis  Download fulltext PDF

Autor: Eleni Bazigou - Taija Makinen

Fuente: https://link.springer.com/

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