Melan-A-MART-1 immunity in a EWS-ATF1 translocated clear cell sarcoma patient treated with sunitinib: a case reportReportar como inadecuado




Melan-A-MART-1 immunity in a EWS-ATF1 translocated clear cell sarcoma patient treated with sunitinib: a case report - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Cancer

, 15:58

Infection, immunity and cancer vaccines

Abstract

BackgroundClear cell sarcoma CCS, initially named malignant melanoma of soft parts, is an aggressive soft tissue sarcoma STS that, due to MITF activation, shares with melanoma the expression of melanocyte differentiation antigens. CCS is poorly sensitive to chemotherapy. Multi-kinase inhibitors have been used as therapeutic agents. In the case we report here, treatment with sunitinib induced a long-lasting clinical response that was associated with an immune activation directed against Melan-A-MART-1 antigen.

Case presentationA 28 years old female patient with an advanced molecularly confirmed CCS resistant to conventional chemotherapy was started in January 2012 on sunitinib, 37.5 mg-day, with evidence of radiologic and metabolic response at the primary and metastatic sites of disease. Pathologic response and loss of the Melan-A-MART-1 antigen were evidenced on residual tumor removed in April 2012. Immunological monitoring performed on patient’s blood during pharmacological treatment revealed a systemic, Melan-A-MART-1 specific immunity and a low frequency of immunosuppressive cells. Sunitinib was restarted in May 2012, with a new response, and continued for 11 months although with repeatedly interruptions due to toxicity. Disease progression and new responses were documented at each treatment interruption and restart. Sunitinib was definitively interrupted in April 2013 for disease progression.

ConclusionThe analysis of this case proves that antigens expressed by CCS, as for melanoma, can be immunogenic in vivo and that tumor-antigen specific T cells may exert anti-tumor activity in CCS patient. Thus, manipulation of the immune response may have therapeutic potential for this STS subtype and immunotherapy approaches, can be promising therapeutic options for these patients.

KeywordsSarcoma Sunitinib Clear cell sarcoma Tumor-specific T cell Immunotherapy Chemotherapy  Download fulltext PDF



Autor: Marcella Tazzari - Elena Palassini - Barbara Vergani - Antonello Villa - Francesca Rini - Tiziana Negri - Chiara Colombo -

Fuente: https://link.springer.com/







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