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Journal of Medical Case Reports

, 4:189

First Online: 22 June 2010Received: 28 October 2009Accepted: 22 June 2010DOI: 10.1186-1752-1947-4-189

Cite this article as: Bolster, L., Taylor-Gjevre, R.M., Nair, B. et al. J Med Case Reports 2010 4: 189. doi:10.1186-1752-1947-4-189


IntroductionAnticentromere antibodies have been associated with peripheral vascular occlusive disease, most frequently accompanied by sclerodactyly in the context of a connective tissue disorder. We report a case of digital gangrene with no other clinical associations except positive anticentromere antibodies.

Case presentationOur patient, a 53-year-old Caucasian woman, non-smoker, presented with progressive pain and blackening of the distal right third finger over the preceding five weeks. No sclerodactyly was evident. She was anticentromere antibody positive at greater than 100 U-mL. Angiography revealed diffuse distal vasculopathy in both upper extremities. Other investigations were unremarkable.

ConclusionsIt is rare for anticentromere antibody-associated digital necrosis to develop without concomitant sclerodactyly. However, this patient-s case illustrates the need to consider an autoimmune contribution to the pathogenesis of digital ischemia even in the absence of a recognizable connective tissue disease.

Electronic supplementary materialThe online version of this article doi:10.1186-1752-1947-4-189 contains supplementary material, which is available to authorized users.

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Author: Lauren Bolster - Regina M Taylor-Gjevre - Bindu Nair - John A Gjevre


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