Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: effects of preoperative chemotherapyReportar como inadecuado




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BMC Cancer

, 10:320

First Online: 22 June 2010Received: 04 September 2009Accepted: 22 June 2010DOI: 10.1186-1471-2407-10-320

Cite this article as: Koda, M., Kanczuga-Koda, L., Sulkowska, M. et al. BMC Cancer 2010 10: 320. doi:10.1186-1471-2407-10-320

Abstract

BackgroundTumor hypoxia is marked by enhanced expression of hypoxia-inducible factor-α HIF-1α and glucose transporter-1 Glut-1. Hypoxic conditions have also been associated with overexpression of angiogenic factors, such as leptin. The aim of our study was to analyze the relationships between hypoxia markers HIF-1α, Glut-1, leptin, leptin receptor ObR and other breast cancer biomarkers in primary and metastatic breast cancer in patients treated or untreated with preoperative chemotherapy.

MethodsThe expression of different biomarkers was examined by immunohistochemistry in 116 primary breast cancers and 65 lymph node metastases. Forty five of these samples were obtained form patients who received preoperative chemotherapy and 71 from untreated patients.

ResultsIn primary tumors without preoperative chemotherapy, HIF-1α and Glut-1 were positively correlated p = 0.02, r = 0.437. HIF-1α in primary and metastatic tumors without preoperative therapy positively correlated with leptin p < 0.0001, r = 0.532; p = 0.013, r = 0.533, respectively and ObR p = 0.002, r = 0.319; p = 0.083, r = 0.387, respectively. Hypoxia markers HIF-1α and Glut-1 were negatively associated with estrogen receptor alpha ERα and positively correlated with estrogen receptor beta ERβ. In this group of tumors, a positive correlation between Glut-1 and proliferation marker Ki-67 p = 0.017, r = 0.433 was noted. The associations between HIF-1α and Glut-1, HIF-1α and leptin, HIF-1α and ERα as well as Glut-1 and ERβ were lost following preoperative chemotherapy.

ConclusionsIntratumoral hypoxia in breast cancer is marked by coordinated expression of such markers as HIF-1α, Glut-1, leptin and ObR. The relationships among these proteins can be altered by preoperative chemotherapy.

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Autor: Mariusz Koda - Luiza Kanczuga-Koda - Mariola Sulkowska - Eva Surmacz - Stanislaw Sulkowski

Fuente: https://link.springer.com/







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