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Journal of Translational Medicine

, 8:49



BackgroundToll-like receptors TLRs recognize pathogen-associated molecular patterns and play a crucial role in the host-s innate immune response. Genetic variations in TLR genes may influence host-viral interactions and might impact upon the risk of mother-to-child transmission MTCT of Human Immunodeficiency Virus type 1 HIV-1. The aim of this study was to investigate the influence of genetic variants of TLR 9 gene on MTCT.

MethodsThree hundred children 118 HIV-1-infected and 182 HIV-1-uninfected born to HIV-1-infected mothers were studied. Single nucleotide polymorphisms SNPs NM 017442.2: c.4-44G > A rs352139 and c.1635A > G rs352140 of the TLR9 gene were genotyped by TaqMan allelic discrimination assay. Statistical analyses were performed using SNPStats program.

ResultsWhen considered separately, neither of the two SNPs was significantly associated with risk of HIV-1 infection. However, the A;A and G;G haplotypes were associated with a higher risk of HIV-1 infection compared to the prevalent G;A haplotype odds ratio OR = 3.16, 95% confidence interval CI 1.24-8.03, p = 0.016, and OR = 5.54, 95% CI 1.76-17.50, p = 0.004, respectively.

ConclusionsOverall, results demonstrate a significant correlation between specific genetic variants of the TLR9 gene and risk of MTCT of HIV-1, thus confirming a critical role of innate immunity in perinatal HIV-1 infection. Strategies aimed at modulating innate immunity might be useful for future treatment of pediatric HIV-1 infection and AIDS.

List of abbreviationsCIconfidence intervals

HIV-1Human Immunodeficiency Virus type 1

MTCTmother-to-child transmission

ORodds ratio

SNPsingle nucleotide polymorphism

TLRToll-like receptor.

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Autor: Elisabetta Ricci - Sandro Malacrida - Marisa Zanchetta - Ilaria Mosconi - Marco Montagna - Carlo Giaquinto - Anita De Rossi



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