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BMC Research Notes

, 6:172

First Online: 01 May 2013Received: 27 November 2012Accepted: 19 April 2013DOI: 10.1186-1756-0500-6-172

Cite this article as: López-Rocha, E., Juárez-Álvarez, J., Riego-Ruiz, L. et al. BMC Res Notes 2013 6: 172. doi:10.1186-1756-0500-6-172


BackgroundAlthough epidemiologic and socioeconomic criteria and biomedical risk factors indicate high-priority for tuberculosis TB control in Mexico, molecular epidemiology studies of the disease in the country are scarce.

MethodsComplete sociodemographic and clinical data were obtained from 248 of the 432 pulmonary TB PTB cases confirmed from 2006 to 2010 on the population under epidemiological surveillance in the state of San Luis Potosí, México. From most PTB cases with complete data Mycobacterium tuberculosis complex MTC isolates were recovered and their spoligotypes, lineages and families, geographic distribution and drug resistance determined.

ResultsPulmonary tuberculosis incidence ranged from 2.4 to 33.4 cases per 100,000 inhabitants in the six state sanitary jurisdictions that were grouped in regions of low jurisdictions I-II-III, intermediate jurisdictions IV-V and high incidence jurisdiction VI with 6.2, 17.3 and 33.4 rates, respectively. Most patients were poor, 50-years-median-age males and housewives. Among the 237 MTC spoligotyped isolates, 232 corresponded to M. tuberculosis 104 spoligotypes in 24 clusters and five to M. bovis. The predominant Euro-American lineage was distributed all over the state, the East-Asian lineage Beijing family in the capital city, the Indo-Oceanic Manila family in eastern localities, and M. bovis in rural localities.

ConclusionsIn San Luis Potosí TB affects mainly poor male adults and is caused by M. tuberculosis and to a minor extent by M. bovis. There is great genotypic diversity among M. tuberculosis strains, the Euro-American lineage being much more prevalent than the Indo-Oceanic and East-Asian lineages. The frequency of resistant strains is relatively low and not associated to any particular lineage.

KeywordsTuberculosis Mycobacterium bovis Spoligotypes Molecular epidemiology San Luis Potosí Mexico Social determinants of tuberculosis Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-6-172 contains supplementary material, which is available to authorized users.

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Autor: Estela López-Rocha - Julio Juárez-Álvarez - Lina Riego-Ruiz - Leonor Enciso-Moreno - Francisco Ortega-Aguilar - Julián H


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