Brain homeostasis: VEGF receptor 1 and 2—two unequal brothers in mindReportar como inadecuado

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Cellular and Molecular Life Sciences

, Volume 70, Issue 10, pp 1705–1725

First Online: 12 March 2013Received: 15 January 2013Revised: 28 January 2013Accepted: 28 January 2013DOI: 10.1007-s00018-013-1279-3

Cite this article as: Wittko-Schneider, I.M., Schneider, F.T. & Plate, K.H. Cell. Mol. Life Sci. 2013 70: 1705. doi:10.1007-s00018-013-1279-3


Vascular endothelial growth factors VEGFs, initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood. Therefore, the VEGF system serves as a promising therapeutic target for brain pathologies, but its simultaneous action on vascular cells paves the way for harmful side effects. To circumvent these deleterious effects, many studies have aimed to clarify whether VEGFs directly affect neural cells or if the effects are mediated secondarily via other cell types, like vascular cells. A great number of reports have shown the expression and function of VEGF receptors VEGFRs, mainly VEGFR-1 and -2, in neural cells, where VEGFR-2 has been described as the major mediator of VEGF-A signals. This review aims to summarize and compare the divergent roles of VEGFR-1 and -2 during CNS development and homeostasis.

KeywordsVEGF receptors Neurogenesis Neural stem cells Brain development Brain repair Migration  Download fulltext PDF

Autor: Ina M. Wittko-Schneider - Fabian T. Schneider - Karl H. Plate


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