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Journal of Otolaryngology - Head and Neck Surgery

, 44:12

First Online: 12 March 2015Received: 14 August 2014Accepted: 12 February 2015DOI: 10.1186-s40463-015-0063-9

Cite this article as: Le, A.R., Thompson, G.W. & Hoyt, B.J.A. J of Otolaryngol - Head & Neck Surg 2015 44: 12. doi:10.1186-s40463-015-0063-9

Abstract

BackgroundThyroid cancer rates are on the rise worldwide with over 5000 new cases estimated in Canada in 2012. The American Thyroid Association recommends the use of fine-needle aspiration biopsy FNA in the workup of thyroid nodules. Studies show that thyroid FNA accuracy may vary based on interpretation by cytopathologists in academic versus community centres. To date, there has been no literature published addressing the accuracy or utility of preoperative FNA in a Canadian community center. Our goals were to demonstrate the accuracy of thyroid FNA at our centre, and to compare our results to those published in the literature.

MethodsMedical records for patients who underwent thyroidectomy performed by two otolaryngologists in Fredericton, NB, between September 2008 and February 2013 were reviewed. 125 patients with 197 FNAs were analyzed. Fisher’s Exact test was used to compare the malignancy rates in each FNA category, and Chi-Square test was used for FNA distribution comparison.

ResultsThe distribution of all FNA diagnoses at our centre was as follows: 38 19% benign, 100 51% inconclusive, 8 4% suspicious for malignancy, 2 1% malignant, and 49 25% unsatisfactory. FNA distribution was significantly different between our centre and comparison centres Chi-Square p < 0.05. Our malignancy rates within each category using each FNA sample as a data point were 26.3%, 29.0%, 75%, 100% and 12.2% respectively. Comparison to other community studies revealed that we have significantly higher malignancy rates with benign FNAs Fisher’s exact p = <0.05. Analysis using our most malignant FNA data yielded similar results.

ConclusionThyroid FNA accuracy varies between institutions, and this may affect its utility in the workup of a thyroid nodule at some centres. Expert cytopathology opinions may be an asset in interpreting FNA samples in small community centres where volumes are relatively low, however our data do not support this assertion. It is essential that physicians continue to use clinical judgment first and foremost when evaluating thyroid nodules.

KeywordsFine-needle aspiration FNA Thyroid Nodule Cytopathology Thyroid cancer Community AbbreviationsFNAFine-needle aspiration biopsy

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Autor: Andre R Le - Gregory W Thompson - Benjamin John A Hoyt

Fuente: https://link.springer.com/







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