The use of tacrolimus for recurrent lupus enteritis: a case reportReport as inadecuate

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Journal of Medical Case Reports

, 4:150

First Online: 24 May 2010Received: 05 November 2009Accepted: 24 May 2010DOI: 10.1186-1752-1947-4-150

Cite this article as: Shirai, T., Hirabayashi, Y., Watanabe, R. et al. J Med Case Reports 2010 4: 150. doi:10.1186-1752-1947-4-150


IntroductionPatients with lupus enteritis sometimes experience recurrence. In such cases, the addition of cyclophosphamide to the treatment regimen is recommended. However, an appropriate treatment has not been established in cases where cyclophosphamide failed to prevent the disease.

Case presentationAn 18-year-old Japanese woman was admitted for a recurrence of lupus enteritis. One year before admission she was treated for lupus enteritis with high-dose corticosteroid together with intravenous cyclophosphamide pulse therapy. Upon admission, she was administered again with high-dose corticosteroid and her abdominal pain rapidly subsided. Tacrolimus was later used as an immunosuppressive agent and a complete remission has been maintained.

ConclusionTacrolimus can be a useful agent for recurrent lupus enteritis that is resistant to conventional therapy.


ALTalanine aminotransferase

ALPalkaline phosphatase


ANCAanti-neutrophil cytoplasmic antibodies

Anti-beta2-GPIanti-beta2-glycoprotein I

APTTactivated partial thromboplastin time

ASTaspartate aminotransferase

BUNblood urea nitrogen

CH5050% hemolytic complement activity



CRPC-reactive protein


FDPfibrin degradation product


LDHlactate dehydrogenase




RBCred blood cells

SAAserum amyloid protein A

T-Biltotal bilirubin

TPtotal protein

WBCwhite blood cells


Electronic supplementary materialThe online version of this article doi:10.1186-1752-1947-4-150 contains supplementary material, which is available to authorized users.

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Author: Tsuyoshi Shirai - Yasuhiko Hirabayashi - Ryu Watanabe - Yumi Tajima - Hiroshi Fujii - Naruhiko Takasawa - Tomonori Ishii -


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