New insights of P2X7 receptor signaling pathway in alveolar functionsReport as inadecuate

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Journal of Biomedical Science

, 20:26

First Online: 01 May 2013Received: 01 March 2013Accepted: 29 April 2013DOI: 10.1186-1423-0127-20-26

Cite this article as: Mishra, A. J Biomed Sci 2013 20: 26. doi:10.1186-1423-0127-20-26


Purinergic P2X7 receptor P2X7R, an ATP-gated cation channel, is unique among all other family members because of its ability to respond to various stimuli and to modulate pro-inflammatory signaling. The activation of P2X7R in immune cells is absolutely required for mature interleukin -1beta IL-1beta and IL-18 production and release. Lung alveoli are lined by the structural alveolar epithelial type I AEC I and alveolar epithelial type II cells AEC II. AEC I plays important roles in alveolar barrier protection and fluid homeostasis whereas AEC II synthesizes and secrete surfactant and prevents alveoli from collapse. Earlier studies indicated that purinergic P2X7 receptors were specifically expressed in AEC I. However, their implication in alveolar functions has not been explored. This paper reviews two important signaling pathways of P2X7 receptors in surfactant homeostatsis and Acute Lung Injury ALI. Thus, P2X7R resides at the critical nexus of alveolar pathophysiology.

Electronic supplementary materialThe online version of this article doi:10.1186-1423-0127-20-26 contains supplementary material, which is available to authorized users.

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Author: Amarjit Mishra


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