Clinical application of circulating tumor cells in breast cancer: overview of the current interventional trialsReport as inadecuate

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Cancer and Metastasis Reviews

, Volume 32, Issue 1–2, pp 179–188

First Online: 06 November 2012DOI: 10.1007-s10555-012-9398-0

Cite this article as: Bidard, FC., Fehm, T., Ignatiadis, M. et al. Cancer Metastasis Rev 2013 32: 179. doi:10.1007-s10555-012-9398-0


In 2004, circulating tumor cells CTC enumeration by the CellSearch® technique at baseline and during treatment was reported to be associated with prognosis in metastatic breast cancer patients. In 2008, the first evidence of the impact of CTC detection by this technique on survival of cM0i+ patients were reported. These findings were confirmed by other non-interventional studies, whereas CTC were also investigated as a surrogate for tumor biology, mainly for HER2 expression-amplification. The aim of this report is to present the current prospective large interventional studies that have been specifically designed to demonstrate that CTC enumeration-characterization may improve the management of breast cancer patients: STIC CTC METABREAST France and Endocrine Therapy Index USA assess the CTC-guided hormone therapy vs chemotherapy decision in M1 patients; SWOG0500 USA and CirCe01 France assess the CTC count changes during treatment in metastatic patients; DETECT III M1 patients, Germany and Treat CTC cM0i+ patients, European Organization for Research and Treatment of Cancer-Breast International Group assess the use of anti-HER2 treatments in HER2-negative breast cancer patients selected on the basis of CTC detection-characterization. These trials have different designs in various patient populations but are expected to be the pivotal trials for CTC implementation in the routine management of breast cancer patients.

KeywordsBreast cancer CellSearch® Circulating tumor cells  Download fulltext PDF

Author: François-Clément Bidard - Tanja Fehm - Michail Ignatiadis - Jeffrey B. Smerage - Catherine Alix-Panabières - Wolfgang Ja


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