Influence of a six month endurance exercise program on the immune function of prostate cancer patients undergoing Antiandrogen- or Chemotherapy: design and rationale of the ProImmun studyReportar como inadecuado

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BMC Cancer

, 13:272

Epidemiology, prevention and public health


BackgroundExercise seems to minimize prostate cancer specific mortality risk and treatment related side effects like fatigue and incontinence. However the influence of physical activity on the immunological level remains uncertain. Even prostate cancer patients undergoing palliative treatment often have a relatively long life span compared to other cancer entities. To optimize exercise programs and their outcomes it is essential to investigate the underlying mechanisms. Further, it is important to discriminate between different exercise protocols and therapy regimes.

Methods-DesignThe ProImmun study is a prospective multicenter patient preference randomized controlled trial investigating the influence of a 24 week endurance exercise program in 80–100 prostate cancer patients by comparing patients undergoing Antiandrogen therapy combined with exercise AE, Antiandrogen therapy without exercise A, Chemotherapy with exerciseCE or Chemotherapy without exercise C. The primary outcome of the study is a change in prostate cancer relevant cytokines and hormones IL-6, MIF, IGF-1, Testosterone. Secondary endpoints are immune cell ratios, oxidative stress and antioxidative capacity levels, VO2 peak, fatigue and quality of life. Patients of the intervention group exercise five times per week, while two sessions are supervised. During the supervised sessions patients AE and CE exercise for 33 minutes on a bicycle ergometer at 70-75% of their VO2 peak. To assess long term effects and sustainability of the intervention two follow-up assessments are arranged 12 and 18 month after the intervention.

DiscussionThe ProImmun study is the first trial which primarily investigates immunological effects of a six month endurance exercise program in prostate cancer patients during palliative care. Separating patients treated with Antiandrogen therapy from those who are additionally treated with Chemotherapy might allow a more specific view on the influence of endurance training interventions and the impact of different therapy protocols on the immune function.

Trial registrationGerman Clinical Trials Register: DRKS00004739

KeywordsExercise Prostate cancer Immune function AbbreviationsNYHANew York Heart Association

MIFMacrophage migration inhibiting factor


IL-6Interleukin 6

IGF-1Insulin like Growth Factor

CDCluster of Differentiation

ELISAEnzyme-Linked Immunosorbent Assay

FORMplusFree Oxygen Radicals Monitors

EORTC-QLQ-C30European Organization for the Research and Treatment of Cancer- Quality of Life Questionnaire-Cancer

EORTC-QLQ-PR25European organization for the research and treatment of cancer- quality of life questionnaire- prostate cancer

MFI-20Multidimensional Fatigue Inventory

WHOWorld Health Organization

VO2 peakHighest O2 consumption during the test

METMetabolic equivalent.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-13-272 contains supplementary material, which is available to authorized users.

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Autor: Philipp Zimmer - Elke Jäger - Wilhelm Bloch - Eva Maria Zopf - Freerk T Baumann


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