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BMC Research Notes

, 6:256

First Online: 07 July 2013Received: 07 February 2013Accepted: 03 July 2013DOI: 10.1186-1756-0500-6-256

Cite this article as: Tanaka, S., Takase, H., Dohi, Y. et al. BMC Res Notes 2013 6: 256. doi:10.1186-1756-0500-6-256

Abstract

BackgroundMicroalbuminuria is a marker of cardiovascular events. This study investigated the prevalence of microalbuminuria in the general population and the factors that can affect urinary excretion of albumin.

MethodsApparently healthy subjects who participated in a health checkup at our hospital were enrolled in this study n = 7963, male 64.0%, 56.2 ± 11.8 years old Urine samples were collected for the measurement of albumin concentrations, which were expressed as the ratio of urinary albumin to creatinine concentrations UACR mg-g Cr. Individual salt intake was assessed by estimating the 24-hour urinary salt excretion of subjects.

ResultsThe mean blood pressure was 124 ± 15-76 ± 10 mmHg and 31.6%, 7.4%, and 44.1% of subjects had hypertension, diabetes mellitus, and dyslipidemia, respectively. Urinary albumin was detected in 7265 subjects 91.2%: UACR ≥ 300 mg-g Cr, 0.5%; 300 > UACR ≥ 30 mg-g Cr, 4.6%; 30 > UACR ≥ 20 mg-g Cr, 2.4%; 20 > UACR ≥ 10 mg-g Cr, 8.7%; 10 > UACR ≥ 5 mg-g Cr, 21.8%; UACR < 5 mg-g Cr, 53.2%. In subjects with detectable albuminuria, UACR was independently correlated with age, systolic blood pressure, serum creatinine, fasting plasma glucose, and salt intake after adjustment for possible factors P < 0.0001.

ConclusionThe prevalence of microalbuminuria was found to be 4.6% in the general population. The urinary excretion of albumin was closely associated with blood pressure and salt intake. These data indicated the importance of salt restriction for the prevention of cardiovascular disease and end-stage renal disease.

KeywordsBlood pressure General population Hypertension Microalbuminuria Salt AbbreviationsUACRThe ratio of urinary albumin to creatinine concentrations

CrCreatinine

ECGElectrocardiogram

SBPSystolic blood pressure

DBPDiastolic blood pressure

LDL-cholesterolLow-density lipoprotein-cholesterol

HDL-cholesterolHigh-density lipoprotein-cholesterol.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-6-256 contains supplementary material, which is available to authorized users.

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Autor: Satoru Tanaka - Hiroyuki Takase - Yasuaki Dohi - Genjiro Kimura

Fuente: https://link.springer.com/







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