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BMC Cancer

, 10:1

First Online: 04 January 2010Received: 15 July 2009Accepted: 04 January 2010DOI: 10.1186-1471-2407-10-1

Cite this article as: Cherrier, M.M., Borghesani, P.R., Shelton, A.L. et al. BMC Cancer 2010 10: 1. doi:10.1186-1471-2407-10-1


BackgroundA common treatment option for men with prostate cancer is androgen deprivation therapy ADT. However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiatric and cognitive side effects.

MethodsIn this study, hormone naïve patients without evidence of metastases with a rising PSA were treated with nine months of ADT. Functional magnetic resonance imaging fMRI of the brain during three visuospatial tasks was performed at baseline prior to treatment and after nine months of ADT in five subjects. Seven healthy control patients, underwent neuroimaging at the same time intervals.

ResultsADT patients showed reduced, task-related BOLD-fMRI activation during treatment that was not observed in control subjects. Reduction in activation in right parietal-occipital regions from baseline was observed during recall of the spatial location of objects and mental rotation.

ConclusionsFindings, while preliminary, suggest that ADT reduces task-related neural activation in brain regions that are involved in mental rotation and accurate recall of spatial information.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-10-1 contains supplementary material, which is available to authorized users.

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Author: Monique M Cherrier - Paul R Borghesani - Amy L Shelton - Celestia S Higano


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