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Systematic Reviews

, 4:67

First Online: 10 May 2015Received: 15 January 2015Accepted: 20 April 2015DOI: 10.1186-s13643-015-0051-1

Cite this article as: Swaleh, R., Zeng, L., Mbuagbaw, L. et al. Syst Rev 2015 4: 67. doi:10.1186-s13643-015-0051-1


BackgroundDespite the increasing prevalence of pre-diabetes worldwide, there is insufficient literature on the impact of gestational pre-diabetes on offspring outcomes. The objective of this systematic review is to determine the risk of developing adverse outcomes for the offspring in women with pre-diabetes compared to women with normal glucose levels and women with gestational diabetes mellitus.

Methods-designA systematic search of the published literature will be conducted for experimental and observational studies that report outcomes in the offspring of mothers with pre-diabetes during pregnancy. Databases including EMBASE, PsycINFO, and PubMed will be searched from 1979 the year when the terms impaired glucose tolerance and pre-diabetes were coined to December 2014. Screening of identified articles and data extraction will be conducted in duplicate and independently. Methodological quality of the included studies will be assessed using the Newcastle-Ottawa scale. Discrepancies will be resolved by consensus or by consulting a third author. Meta-analyses will be performed, and findings will be reported according to the preferred reporting items for systematic reviews and meta-analyses PRISMA and the meta-analysis of observational studies in epidemiology MOOSE guidelines.

DiscussionDetermining the effect of pre-diabetes on offspring outcome will be important for clinicians providing care to pregnant women and their offspring. This review will also identify any gaps in the current literature on this topic and provide direction for future research in this area of study.

Systematic review registrationPROSPERO CRD42015015536

KeywordsPre-diabetes Impaired fasting glucose Glucose intolerance Hyperglycemia Offspring outcome AbbreviationsBMIbody mass index

GCTglucose challenge test

GDMgestational diabetes mellitus

HDLchigh-density lipoprotein levels

LDLclow-density lipoprotein levels

NOSNewcastle-Ottawa scale

OGTToral glucose tolerance test

SDstandard deviation

T2DMtype 2 diabetes mellitus

Rukia Swaleh and Ling Zeng contributed equally to this work.

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Autor: Rukia Swaleh - Ling Zeng - Lawrence Mbuagbaw - Katherine M Morrison

Fuente: https://link.springer.com/

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