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Journal of Clinical Bioinformatics

, 3:17

Biomedical RNA interactions


The microRNA miR-155 is prominent in cancer biology. Among microRNAs that have been linked to cancer, it is the most commonly overexpressed in malignancies PNAS 109:20047-20052, 2012. Since its discovery, miR-155 has been implicated in promoting cancers of the breast, lung, liver, and lymphatic system. As such, targeted therapies may prove beneficial to cancer treatment. This review discusses the important role of miR-155 in oncogenesis. It synthesizes information from ten recent papers on miR-155, and includes an analysis and discussion of its association with cancer, interactions with other miRNAs, mechanisms of action, and the most promising available treatment options.

Current debates in the field include the importance of miRNAs in general and their utility as targets in preventing tumorigenesis Blood 119:513-520, 2012. Most of the papers being reviewed here confirm the role of miR-155 in oncogenesis EMBO Mol Med 1:288-295, 2009. While there is some controversy surrounding recent research that claims that miR-155 may display anti-oncogenic or pro-immunological benefits Cell Rep 2:1697–1709, 2012, most research seems to point to the importance of anti-miRs, with anti-miR-155 in particular, for cancer therapy.

KeywordsmiR-155 Oncogenesis OncomiRs Anti-miR therapy Nanoparticle delivery AbbreviationsAHRAryl hydrocarbon receptor

AIDActivation-induced deaminase

ALDH1A1Aldehyde dehydrogenase 1 family, member A1

AMLAcute myeloid leukemia

ANPEPAlanine aminopeptidase

AP-1Activator protein-1

ASGRAsialoglycoprotein receptor

ATF2Activating transcription factor 2

BICB-Cell Integration Cluster

C-MAFMusculoaponeurotic fibrosarcoma oncogene homolog

C-EBP-BetaCCAAT-enhancer-binding protein beta

C3Classical Complement Pathway C3-convertase

CCL5Chemokine C-C motif ligand 5

CCNA2Cyclin A2

CD40Cluster of differentiation 40

CDC20Cell-division cycle protein 20

CDK1Cyclin-dependent kinase 1

CDK6Cyclin-dependent kinase 6

CHEK1Checkpoint kinase 1

CK1-αCasein kinase 1-α

CLEC7AC-type lectin domain family 7, member A

DHFRDihydrofolate reductase

DLBCLDiffuse large B-cell lymphoma

DUSP4Dual specificity protein phosphatase 4

E2F1Higher Eukaryote Transcription Factor 1

EIF2AK2Eukaryotic translation initiation factor 2-alpha kinase 2

ERKExtracellular-signal-regulated kinases ERKs or classical MAP kinases

ESPL1Extra spindle pole bodies homolog 1

ESR1Estrogen Receptor 1

ETS-1Erythroblastosis virus E26 oncogene homolog 1

ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 avian

FANTOMFunctional ANnoTation Of Mammals

FCER1GFc fragment of IgE, high affinity 1 receptor for gamma polypeptide

FOXO3Forkhead box O3

G6PDGlucose-6-phosphate dehydrogenase

GADD45AGrowth arrest and DNA-damage-inducible, alpha

GCLMGlutamate-cysteine ligase, modifier

GLRXGlutaredoxin thioltransferase

GSRGlutathione reductase

GSTM5Glutathione S-transferase mu 5

GSTO1Glutathione S-transferase omega 1

HCCHepatocellular carcinoma cells

HDAC4Histone deacetylase 4

HK2Hexokinase 2

ID2Inhibitor of DNA binding 2

IDH2Isocitrate dehydrogenase 2 NADP+, mitochondrial

IFIH1Interferon induced with helicase C domain 1

IGHG1Immunoglobulin heavy constant gamma 1 G1m marker

IKBKBInhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

IKK-ϵInhibitor of nuclear factor kappa-B kinase subunit epsilon


JAK-STATJanus Kinase-signal transducer and activator of transcription pathway BCL2, B-cell CLL-lymphoma 2

Jun-BJun B proto-oncogene

KIF11Kinesin family member 11

KIF23Kinesin family member 23

KRASKirsten rat sarcoma viral oncogene homolog

Lac-DOPEN-lactobionyl-dioleoyl phosphatidylethanolamine

Lac-GLNLactosylated gramicidin-containing lipid nanoparticles

MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4

MAPK12Mitogen-activated protein kinase 12

MGST1Microsomal glutathione S-transferase 1

MGST2Microsomal glutathione S-transferase 2

MiP1-alphaMacrophage inflammatory protein alpha



MLH1MutL homolog 1

MMTV-PyMTMouse mammary tumor virus-polyoma middle T antigen

MSH2-6MutS protein homolog 2-6

MYCV-myc myelocytomatosis viral oncogene homolog avian

NFIXNuclear factor I-X

NQO2NADPH dehydrogenase, quinone 2

OAS12′-5′-oligoadenylate synthetase 1

oncomiROncogenic microRNA

PIK3R6Phosphoinositide-3-kinase, regulatory subunit 1

PLK1Polio-like kinase 1

PLK4Polo-like kinase 4

PMAPhorbol myristate acetate

POLA1Polymerase DNA directed alpha 1

PRC1Protein regulator of cytokinesis 1

RAPGEF4Rap guanine nucleotide exchange factor 4

RHEBRas homolog enriched in brain

RHOARas homolog gene family, member A

RNASELRibonuclease L

RNPEPArginyl aminopeptidase aminopeptidase B

RPS6KA3Ribosomal protein S6 kinase, 90 kDa, polypeptide 3

SAPK-JNKMitogen-activated protein kinase 9, JUN N-terminal kinase

SGK3Serum-glucocorticoid regulated kinase family, member 3

SHIP1SH2 domain containing inositol-5-phosphatase

siRNASmall interfering RNA

SOCS1Suppressor of cytokine signaling 1

STAT2Signal transducer and activator of transcription 2

STAT3Signal Transducer and Activator of Transcription 3

TAMTumor-associated macrophage

TFDP1Transcription factor dimerization partner 1

TGM2Transglutaminase 2

THP-1Tamm-Horsfall protein 1

TLR7Toll-like receptor 7

TNFTumor necrotic factor

TNFSF13Tumor necrosis factor ligand superfamily, member 13

TP53INP1Tumor protein 53-inducible nuclear protein 1.

Electronic supplementary materialThe online version of this article doi:10.1186-2043-9113-3-17 contains supplementary material, which is available to authorized users.

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Autor: Gadareth Higgs - Frank Slack


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