The relationship between glasgow prognostic score and serum tumor markers in patients with advanced non-small cell lung cancerReport as inadecuate

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BMC Cancer

, 15:386

Clinical oncology


BackgroundGlasgow Prognostic Score GPS has been reported as a powerful prognostic tool for patients with advanced non–small cell lung cancer NSCLC. The aim of this study was to assess the relationship between GPS and prognosis related tumor markers in patients with advanced NSCLC.

MethodsWe included 138 advanced NSCLC patients and twenty healthy controls in the study. GPS was calculated by combined serum C-reactive protein CRP and albumin. Three serum tumor markers, which included cytokeratin 19 fragment antigen 21-1 CYFRA21–1, carcinoembryonic antigen CEA and tissue polypeptide specific antigen TPS, were detected by enzyme-linked immunosorbent assay ELISA. GPS and tumor markers were all assessed before chemotherapy. All patients received at least 2 courses of cisplatin-based chemotherapy. After that, 2 to 5 years follow-up was conducted.

ResultsMedian levels of CYFRA21–1 were 1.5 ng-ml 0.1–3.1 ng-ml in healthy controls, and 4.6 ng-ml 0.7–35.2 ng-ml in GPS 0 advanced NSCLC, 11.2 ng-ml 0.4–89.2 ng-ml in GPS 1 advanced NSCLC, and 15.7 ng-ml 2.9–134.6 ng-ml in GPS 2 advanced NSCLC, respectively. Median levels of CYFRA21-1 were higher in NSCLC patients than in healthy controls, and CYFRA21-1 increased gradually according to GPS category in NSCLC patients P < 0.05. Similar results were found for median levels of CEA and TPS in healthy controls and NSCLC patients P < 0.05. In NSCLC patients, positive correlations were found between CYFRA21-1 and GPS, CEA and GPS, TPS and GPS. The Spearman’s rank correlation coefficient were 0.67 P < 0.05, 0.61 P < 0.05 and 0.55 P < 0.05, respectively. Survival analyses showed GPS was an independent prognostic factor for advanced NSCLC. CYFRA21-1>3.3 ng-ml and TPS >80 U-l were related with the prognosis of advanced NSCLC by univariate analyses, but multivariate analyses showed CYFRA21-1, TPS and CEA were not the independent prognostic factors for advanced NSCLC.

ConclusionsOur results showed GPS were positive correlated with CYFRA21-1, CEA and TPS in patients with advanced NSCLC. However, GPS was more efficient in predicting prognosis of advanced NSCLC than these three single prognosis related tumor markers.

KeywordsAdvanced non-small cell lung cancer Glasgow prognostic score CYFRA21-1 CEA TPS  Download fulltext PDF

Author: Ai-Gui Jiang - Hong-Lin Chen - Hui-Yu Lu


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