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Cancer Causes and Control

, Volume 24, Issue 11, pp 1995–2003

First Online: 09 August 2013Received: 08 May 2013Accepted: 31 July 2013DOI: 10.1007-s10552-013-0275-0

Cite this article as: Friedenreich, C.M., Speidel, T.P., Neilson, H.K. et al. Cancer Causes Control 2013 24: 1995. doi:10.1007-s10552-013-0275-0


PurposeAlcohol consumption is hypothesized to increase the risk of endometrial cancer by increasing circulating estrogen levels. This study sought to investigate the association between lifetime alcohol consumption and endometrial cancer risk.

MethodsWe recruited 514 incident endometrial cancer cases and 962 frequency age-matched controls in this population-based case–control study in Alberta, Canada, from 2002 to 2006. Participants completed in-person interviews querying lifetime alcohol consumption and other relevant health and lifestyle factors. Participants reported the usual number of drinks of beer, wine, and liquor consumed; this information was compiled for each drinking pattern reported over the lifetime to estimate average lifetime exposure to alcohol.

ResultsLifetime average alcohol consumption was relatively low median intake: 3.9 g-day for cases, 4.9 g-day for controls. Compared with lifetime abstainers, women consuming >2.68 and ≤8.04 g-day alcohol and >8.04 g-day alcohol on average over the lifetime showed 38 and 35 % lower risks of endometrial cancer, respectively p trend = 0.023. In addition, average lifetime consumption of all types of alcohol was associated with decreased risks. There was no evidence for effect modification by body mass index, physical activity, menopausal status, and hormone replacement therapy use combined and effects did not differ by type of endometrial cancer type I or II.

ConclusionThis study provides epidemiologic evidence for an inverse association between relatively modest lifetime average alcohol consumption approximately 1-4 to 1-2 drink-day and endometrial cancer risk. The direction of this relation is consistent with previous studies that examined similar levels of alcohol intake.

KeywordsEndometrial cancer Alcohol drinking Ethanol Beer Wine Liquor  Download fulltext PDF



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