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BMC Cancer

, 9:439

First Online: 15 December 2009Received: 04 June 2009Accepted: 15 December 2009DOI: 10.1186-1471-2407-9-439

Cite this article as: Yin, Z., Zhou, B., He, Q. et al. BMC Cancer 2009 9: 439. doi:10.1186-1471-2407-9-439

Abstract

BackgroundExcision repair cross-complementing group 1 ERCC1 and group 2 ERCC2, and X-ray repair cross-complementing group 1 XRCC1 proteins play important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms SNPs of DNA repair genes are suspected to influence treatment effect and survival of cancer patients. This study aimed to investigate the relationship between polymorphisms in ERCC2, ERCC1 and XRCC1 genes and survival of non-smoking female patients with lung adenocarcinoma.

MethodsWe used polymerase chain reaction-restriction fragment length polymorphism PCR-RFLP method to evaluate SNPs in ERCC2, ERCC1 and XRCC1 genes among 257 patients.

ResultsThe overall median survival time MST was 13.07 months. Increasing numbers of either ERCC1 118 or XRCC1 399 variant alleles were associated with shorter survival of non-smoking female lung adenocarcinoma patients Log-rank P < 0.001. The adjusted hazard ratios HRs for individuals with CT or TT genotype at ERCC1 Asn118Asn were 1.48 and 2.67 compared with those with CC genotype. For polymorphism of XRCC1 399, the HRs were 1.28 and 2.68 for GA and AA genotype. When variant alleles across both polymorphisms were combined to analysis, the increasing number of variant alleles was associated with decreasing overall survival. Using the stepwise Cox regression analysis, we found that the polymorphisms in ERCC1 and XRCC1, tumor stage and chemotherapy or radiotherapy status independently predicted overall survival of non-smoking female patients with lung adenocarcinoma.

ConclusionsGenetic polymorphisms in ERCC1 and XRCC1 genes might be prognostic factors in non-smoking female patients with lung adenocarcinoma.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-9-439 contains supplementary material, which is available to authorized users.

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