Expression of nerve growth factor and heme oxygenase-1 predict poor survival of breast carcinoma patientsReportar como inadecuado

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BMC Cancer

, 13:516

Translational oncology


BackgroundNerve growth factor NGF is a neurotrophin and has been suggested to induce heme oxygenase-1 HO1 expression. Although the role of HO1 in tumorigenesis remains controversial, recent evidence suggests NGF and HO1 as tumor-progressing factors. However, the correlative role of NGF and HO1 and their prognostic impact in breast carcinoma is unknown.

MethodsWe investigated the expression and prognostic significance of the expression of NGF and HO1 in 145 cases of breast carcinoma.

ResultsImmunohistochemical expression of NGF and HO1 was observed in 31% and 49% of breast carcinoma, respectively. The expression of NGF and HO1 significantly associated with each other, and both have a significant association with histologic grade, HER2 expression, and latent distant metastasis. The expression of NGF and HO1 predicted shorter overall survival of breast carcinoma by univariate and multivariate analysis. NGF expression was an independent prognostic indicator for relapse-free survival by multivariate analysis. The combined expression pattern of NGF and HO1 was also an independent prognostic indicator of overall survival and relapse-free survival. The patients with tumors expressing NGF had the shortest survival and the patients with tumor, which did not express NGF or HO1 showed the longest survival time.

ConclusionsThis study has demonstrated that individual expression of NGF or HO1, and the combined NGF-HO1 expression pattern could be prognostic indicators for breast carcinoma patients.

KeywordsNerve growth factor Heme oxygenase-1 Carcinoma Breast AbbreviationsBRCABreast carcinoma

CIConfidence interval

EREstrogen receptor

HER2Human epithelial growth factor receptor 2

HO1Heme oxygenase-1

HRHazard ratio

LNLymph node

NGFNerve growth factor

NGFRNerve growth factor receptor

OSOverall survival

PRProgesterone receptor

RFSRelapse-free survival

TMATissue microarray

TrkATropomyosin-related kinase A.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-13-516 contains supplementary material, which is available to authorized users.

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Autor: Sang Jae Noh - Jun Sang Bae - Urangoo Jamiyandorj - Ho Sung Park - Keun Sang Kwon - Sung Hoo Jung - Hyun Jo Youn - Ho


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