SmartArc-based volumetric modulated arc therapy for endometrial cancer: a dosimetric comparison with helical tomotherapy and intensity-modulated radiation therapyReportar como inadecuado




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BMC Cancer

, 13:515

Clinical oncology

Abstract

BackgroundThe purpose of the present study was to investigate the feasibility of using volumetric modulated arc therapy with SmartArc VMAT-S to achieve radiation delivery efficiency higher than that of intensity-modulated radiotherapy IMRT and helical tomotherapy HT when treating endometrial cancer, while maintaining plan quality.

MethodsNine patients with endometrial cancer were retrospectively studied. Three plans per patient were generated for VMAT-S, IMRT and HT. The dose distributions for the planning target volume PTV, organs at risk OARs and normal tissue were compared. The monitor units MUs and treatment delivery time were also evaluated.

ResultsThe average homogeneity index was 1.06, 1.10 and 1.07 for the VMAT-S, IMRT and HT plans, respectively. The V40 for the rectum, bladder and pelvis bone decreased by 9.0%, 3.0% and 3.0%, respectively, in the VMAT-S plan relative to the IMRT plan. The target coverage and sparing of OARs were comparable between the VMAT-S and HT plans. The average MU was 823, 1105 and 8403 for VMAT-S, IMRT and HT, respectively; the average delivery time was 2.6, 8.6 and 9.5 minutes, respectively.

ConclusionsFor endometrial cancer, the VMAT-S plan provided comparable quality with significantly shorter delivery time and fewer MUs than with the IMRT and HT plans. In addition, more homogeneous PTV coverage and superior sparing of OARs in the medium to high dose region were observed in the VMAT-S relative to the IMRT plan.

KeywordsEndometrial cancer Helical tomotherapy Intensity-modulated radiation therapy Volumetric modulated arc therapy AbbreviationsVMAT-SVolumetric modulated arc therapy with SmartArc

IMRTIntensity-modulated radiotherapy

HTHelical tomotherapy

PTVPlanning target volume

CTVClinical target volume

OARsOrgans at risk

NTNormal tissue

MUMonitor unit

WPRTWhole pelvic radiation therapy

MLCMultileaf collimator

TPSTreatment planning system

IDIntegral dose

CIConformity index

HIHeterogeneity index.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-13-515 contains supplementary material, which is available to authorized users.

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Autor: Ruijie Yang - Junjie Wang - Shouping Xu - Hua Li

Fuente: https://link.springer.com/







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