Genome-wide analysis of haplotype interaction for the data from the North American Rheumatoid Arthritis ConsortiumReportar como inadecuado




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BMC Proceedings

, 3:S34

First Online: 15 December 2009DOI: 10.1186-1753-6561-3-S7-S34

Cite this article as: Park, J., Namkung, J., Jhun, M. et al. BMC Proc 2009 3Suppl 7: S34. doi:10.1186-1753-6561-3-S7-S34

Abstract

Recent genome-wide association studies on several complex diseases have focused on individual single-nucleotide polymorphism SNP analysis; however, not many studies have reported interactions among genes perhaps because the gene-gene and gene-environment interaction analysis could be infeasible due to heavy computing requirements. In this study we propose a new strategy for exploring the interactions among haplotypes. The proposed method consists of two steps. Step 1 tests the single-SNP association of whole genome with multiple testing corrections and finds the haplotype blocks of the significant SNPs. Step 2 performs interaction analysis of haplotypes within blocks. Our proposed method is applied to the rheumatoid arthritis data for Genetic Analysis Workshop 16.

List of abbreviations usedGAWGenetic Analysis Workshop

GWAHIGenome-wide analysis of haplotype interaction

GWASGenome-wide association studies

HLAHuman leukocyte antigen

NARACNorth American Rheumatoid Arthritis Consortium

RARheumatoid arthritis

SNPSingle-nucleotide polymorphism.

Electronic supplementary materialThe online version of this article doi:10.1186-1753-6561-3-S7-S34 contains supplementary material, which is available to authorized users.

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Autor: Jungsun Park - Junghyun Namkung - Mina Jhun - Taesung Park

Fuente: https://link.springer.com/







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