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BMC Research Notes

, 2:237

First Online: 26 November 2009Received: 20 May 2009Accepted: 26 November 2009DOI: 10.1186-1756-0500-2-237

Cite this article as: Bocos-Terraz, J.P., Izquierdo-Álvarez, S., Bancalero-Flores, J.L. et al. BMC Res Notes 2009 2: 237. doi:10.1186-1756-0500-2-237


BackgroundThyroid function changes during pregnancy and maternal thyroid dysfunction have been associated with adverse outcomes. Our aim was to evaluate thyroid hormones levels in pregnant women resident in Aragon, Spain.

FindingsSamples for 1198 pregnant women with no apparent thyroid disorders were analyzed, using paramagnetic microparticle and chemiluminescent detection technologies, in order to determine levels of thyroid stimulating hormone TSH, free triiodothyronine FT3, free thyroxine FT4, thyroid peroxidase antibodies TPO-Ab, and thyroglobulin antibodies Tg-Ab. Of the women in our sample, 85.22% had normal values for TPO-Ab and Tg-Ab and 14.77% had results revealing the presence of autoimmune diseases of the thyroid. The thyroid hormone reference values obtained according to gestational age in brackets were as follows: for free T3, values were 3.38 ± 0.52 pg-mL <11 weeks, 3.45 ± 0.54 pg-mL 11-20 weeks, 3.32 ± 0.43 pg-mL 21-30 weeks, 3.21 ± 0.53 pg-mL 31-36 weeks, and 3.23 ± 0.41 pg-mL >36 weeks; for free T4, values were 1.10 ± 0.14 ng-dL <10 weeks, 1.04 ± 0.14 ng-dL 11-20 weeks, 0.93 ± 0.12 ng-dL 21-30 weeks, 0.90 ± 0.13 ng-dL 31-36 weeks, and 0.80 ± 0.21 ng-dL >36 weeks; and for TSH, values were μIU-mL: 1.12 ± 0.69 <10 weeks, 1.05 ± 0.67 11-20 weeks, 1.19 ± 0.60 21-30 weeks, 1.38 ± 0.76 31-36 weeks, and 1.46 ± 0.72 >36 weeks.

ConclusionPregnant women with normal antibody values according to gestational age had values for FT4 and TSH, but not for FT3, that differed to a statistically significant degree. The values we describe can be used as reference values for the Aragon region of Spain.

List of abbreviationsTSHthyroid-stimulating hormone



TPO-Abthyroid peroxidase antibody

Tg-Abthyroglobulin antibody

RLUrelative light unit.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-2-237 contains supplementary material, which is available to authorized users.

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Autor: Julia Pilar Bocos-Terraz - Silvia Izquierdo-Álvarez - Jose Luís Bancalero-Flores - Rosa Álvarez-Lahuerta - Ana Aznar-Sau


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