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Journal of Medical Case Reports

, 9:140

First Online: 13 June 2015Received: 28 September 2014Accepted: 25 May 2015DOI: 10.1186-s13256-015-0621-9

Cite this article as: Makoshi, Z., Perrott, C., Al-Khatani, K. et al. J Med Case Reports 2015 9: 140. doi:10.1186-s13256-015-0621-9


IntroductionColon cancer in pregnancy is uncommon. Only a small number of case reports have been published in the literature on the use of chemotherapeutic drugs during pregnancy. Reports of such cases assist clinicians in further investigating the use of chemotherapy in pregnancy.

Case presentationFOLFOX-6 was administered to a pregnant, 33-year-old Saudi woman with metastatic colon cancer from 22 to 30 weeks of gestation. Her cancer was diagnosed during her pregnancy. She tolerated the chemotherapy well and delivered a full-term baby girl with no obvious harm, and normal development was documented at her 2-year follow-up examination.

ConclusionColon cancer during pregnancy is not easily detected and is difficult to manage. A detailed history and high clinical suspicion are needed in patients who present with symptoms and signs suggestive of malignancy. A multidisciplinary approach with patient involvement is needed to decrease morbidity and mortality caused by both treatment and the cancer in the mother and to limit side effects for the fetus. Further data and long-term follow-up are needed to better understand the potential long-term side effects of chemotherapeutic drugs on offspring.

KeywordsChemotherapy Colorectal cancer FOLFOX Pregnancy Saudi Arabia AbbreviationsCA-125cancer antigen 125

CRCcolorectal cancer

CTcomputed tomography

FOLFIRIfolinic acid 5-fluorouracil and irinotecan

FOLFOXfolinic acid, 5-fluorouracil and oxaliplatin

FOLFOX-62-hour infusion of oxaliplatin 100mg-m and leucovorin 200mg-m, 5-fluorouracil 400mg-m bolus, and 5-fluorouracil 2400mg-m 46-hour infusion


MRImagnetic resonance imaging

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Autor: Ziyad Makoshi - Claire Perrott - Khadija Al-Khatani - Fadia Al-Mohaisen


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