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Clinical and Translational Medicine

, 4:23

First Online: 02 July 2015Received: 30 January 2015Accepted: 19 June 2015DOI: 10.1186-s40169-015-0065-2

Cite this article as: Chen, W. & Ware, L.B. Clin Trans Med 2015 4: 23. doi:10.1186-s40169-015-0065-2

Abstract

Despite improvements in critical care, acute respiratory distress syndrome ARDS remains a devastating clinical problem with high rates of morbidity and mortality. A better understanding of the prognostic factors associated with ARDS is crucial for facilitating risk stratification and developing new therapeutic interventions that aim to improve clinical outcomes. In this article, we present an up-to-date summary of factors that predict mortality in ARDS in four categories: 1 clinical characteristics; 2 physiological parameters and oxygenation; 3 genetic polymorphisms and biomarkers; and 4 scoring systems. In addition, we discuss how a better understanding of clinical and basic pathogenic mechanisms can help to inform prognostication, decision-making, risk stratification, treatment selection, and improve study design for clinical trials.

KeywordsAcute respiratory distress syndrome Prognostic factors Biomarkers Oxygenation Scoring system  Download fulltext PDF



Autor: Wei Chen - Lorraine B Ware

Fuente: https://link.springer.com/



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