HIV associated thrombocytopenia, misdiagnosed as thrombotic thrombocytopenic purpura: a case reportReport as inadecuate

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Cases Journal

, 2:175

First Online: 29 October 2009Received: 20 July 2008Accepted: 29 October 2009DOI: 10.1186-1757-1626-2-175

Cite this article as: Khorvash, F., Naeini, A.E., Behjati, M. et al. Cases Journal 2009 2: 175. doi:10.1186-1757-1626-2-175


IntroductionThrombocytopenia is one of the protean hematological manifestations of infection by human immunodeficiency virus. We present a case where diagnosis of human immunodeficiency virus infection was delayed because thrombocytopenia was the only presenting feature.

Case presentationA female presented with chief complaint of fever, productive coughs weight loss and nocturnal sweating; was detected to have thrombocytopenia on a complete blood count, performed five months ago. Her other clinical chemistry and hematological investigations were normal. She was previously diagnosed as having TTP, and had received 55 sessions of plasma exchange before presenting to us. At this time she was detected to be HIV positive, had CD4+ counts of 26-mm3, treated with antiretroviral drugs and Cotrimoxazol, and discharged asymptomatically.

ConclusionHIV should be suspected in all cases of unexplained thrombocytopenia.

AbbreviationsCBCCell Blood Count

TTPThrombotic Thrombocytopenic Purpura

ITPImmune Thrombocytopenic Purpura

HIVHuman Immunodeficiency Virus

AIDSAcquired Immunodeficiency Syndrome

ARTActive Retroviral Therapy

Tr-HIVThrombocytopenia related HIV

CXRChest X Ray

IVIGIntra Venus Immunoglobulin


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Author: Farzin Khorvash - Alireza Emami Naeini - Mohadesseh Behjati - Mohammad Jalali


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