Drug resistance patterns of Mycobacterium tuberculosis complex and associated factors among retreatment cases around Jimma, Southwest EthiopiaReportar como inadecuado

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BMC Public Health

, 15:599

First Online: 02 July 2015Received: 02 June 2014Accepted: 19 June 2015DOI: 10.1186-s12889-015-1955-3

Cite this article as: Abdella, K., Abdissa, K., Kebede, W. et al. BMC Public Health 2015 15: 599. doi:10.1186-s12889-015-1955-3


BackgroundInformation on the pattern of drug resistant tuberculosis TB among re-treatment cases is crucial to develop appropriate control strategies. Therefore, we conducted this study to assess the drug resistance pattern of M. tuberculosis complex MTBC isolates and associated factors among re-treatment cases in Jimma area, Southwest Ethiopia.

MethodsHealth facility-based cross-sectional study was conducted between March 2012 and April 2013 in Jimma area, Southwest Ethiopia. We included 79 re-treatment cases selected conveniently. Socio demographic and clinical data were collected using structured questionnaire. Sputum sample processing, mycobacterial culture, isolation and drug susceptibility testing DST were done at Mycobacteriology Research Centre MRC of Jimma University. All data were registered and entered in to SPSS version 20. Crude odds ratio COR and adjusted odds ratios AOR were calculated. P-values less than 0.05 were considered statistically significant.

ResultsSeventy-nine re-treatment cases included in the study; 48 60.8 % were males. Forty- seven 59.5 % study participants were from rural area with the mean age of 31.67 ± 10.02 SD. DST results were available for 70 MTBC isolates. Majority 58.6 % 41-70 isolates were resistant to at least one of the four first line drugs. The prevalence of multidrug-resistant TB MDR-TB was 31.4 % 22-70. Place of residence AOR = 3.44 95 % CI: 1.12, 10.60, duration of illness AOR = 3.00 95 % CI: 1.17, 10.69 and frequency of prior TB therapy AOR = 2.99, 95 % CI: 1.01, 8.86 were significant factors for any drug resistance. Moreover, history of treatment failure was found to be associated with MDR-TB AOR = 3.43 95 % CI: 1.14, 10.28.

ConclusionThe overall prevalence of MDR-TB among re-treatment cases around Jimma was high. The rate of MDR-TB was higher in patients with the history of anti-TB treatment failure. Timely identification and referral of patients with the history of treatment failure for culture and DST need to be strengthened.

KeywordsTuberculosis MDR-TB Drug resistance Drug susceptibility test  Download fulltext PDF

Autor: Kedir Abdella - Ketema Abdissa - Wakjira Kebede - Gemeda Abebe

Fuente: https://link.springer.com/

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