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Asthma Research and Practice

, 1:2

First Online: 02 July 2015Received: 12 December 2014Accepted: 07 May 2015DOI: 10.1186-s40733-015-0004-4

Cite this article as: Bonini, M. & Palange, P. asthma res and pract 2015 1: 2. doi:10.1186-s40733-015-0004-4

Abstract

The acute airway narrowing that occurs as a result of exercise is defined exercise-induced bronchoconstriction EIB. Most recent guidelines recommend distinguishing EIB with underlying clinical asthma EIBA from the occurrence of bronchial obstruction in subjects without other symptoms and signs of asthma EIBwA. EIB has been in fact reported in up to 90 % of asthmatic patients, reflecting the level of disease control, but it may develop even in subjects without clinical asthma, particularly in children, athletes, patients with atopy or rhinitis and following respiratory infections. Both EIBA and EIBwA have peculiar pathogenic mechanisms, diagnostic criteria and responses to treatment and prevention. The use of biomarkers, proteomic approaches and innovative technological procedures will hopefully contribute to better define peculiar phenotypes and to clarify the role of EIB as risk factor for the development of asthma, as well as an occupational disease.

KeywordsExercise Bonchoconstriction Asthma Athlete Sport Doping Phenotypes Biomarkers Beta-2 agonist  Download fulltext PDF



Autor: Matteo Bonini - Paolo Palange

Fuente: https://link.springer.com/







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