The effect of antihypertensive agents on sleep apnea: protocol for a randomized controlled trialReportar como inadecuado

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, 15:1

First Online: 02 January 2014Received: 06 August 2013Accepted: 16 December 2013DOI: 10.1186-1745-6215-15-1

Cite this article as: Cichelero, F.T., Martinez, D., Fuchs, S.C. et al. Trials 2014 15: 1. doi:10.1186-1745-6215-15-1


BackgroundObstructive sleep apnea OSA and hypertension are well-known cardiovascular risk factors. Their control could reduce the burden of heart disease across populations. Several drugs are used to control hypertension, but the only consistently effective treatment of OSA is continuous positive airway pressure. The identification of a drug capable of improving OSA and hypertension simultaneously would provide a novel approach in the treatment of both diseases.

Methods-DesignThis is a randomized double-blind clinical trial, comparing the use of chlorthalidone with amiloride versus amlodipine as a first drug option in patients older than 40 years of age with stage I hypertension 140 to 159-90 to 99 mmHg and moderate OSA 15 to 30 apneas-hour of sleep. The primary outcomes are the variation of the number of apneas per hour and blood pressure measured by ambulatory blood pressure monitoring. The secondary outcomes are adverse events, somnolence scale Epworth, ventilatory parameters and C reactive protein levels. The follow-up will last 8 weeks. There will be 29 participants per group. The project has been approved by the ethics committee of our institution.

DiscussionThe role of fluid retention in OSA has been known for several decades. The use of diuretics are well established in treating hypertension but have never been appropriately tested for sleep apnea. As well as testing the efficacy of these drugs, this study will help to understand the mechanisms that link hypertension and sleep apnea and their treatment.

Trial NCT01896661

KeywordsSleep apnea Hypertension Treatment Diuretics Chlorthalidone Amlodipine AbbreviationsCPAPContinuous positive airway pressure

OSAObstructive sleep apnea.

Electronic supplementary materialThe online version of this article doi:10.1186-1745-6215-15-1 contains supplementary material, which is available to authorized users.

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Autor: Fábio Tremea Cichelero - Denis Martinez - Sandra Costa Fuchs - Miguel Gus - Leila Beltrami Moreira - Flávio Danni Fuch


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