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Molecular and Cellular Therapies

, 2:5



Utilizing RNA interference as an innovative therapeutic strategy has an immense likelihood to generate novel concepts in precision medicine. Several clinical trials are on the way with some positive initial results. Yet, targeting of RNAi payloads such as small interfering RNAs siRNAs, microRNA miR mimetic or anti-miR antagomirs into specific cell types remains a challenge. Major attempts are done for developing nano-sized carriers that could overcome systemic, local and cellular barriers. This progress report will focus on the recent advances in the RNAi world, detailing strategies of systemic passive tissue targeting and active cellular targeting, which is often considered as the holy grail of drug delivery.

KeywordsRNAi siRNAs, Precision medicine Nanomedicine Targeted Nanoparticles Electronic supplementary materialThe online version of this article doi:10.1186-2052-8426-2-5 contains supplementary material, which is available to authorized users.

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Autor: Dan Peer

Fuente: https://link.springer.com/

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