Peritumoral ductular reaction: a poor postoperative prognostic factor for hepatocellular carcinomaReportar como inadecuado

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BMC Cancer

, 14:65

Translational oncology


BackgroundThe role of ductular reaction DR in hepatocellular carcinoma HCC remains to be elucidated.

MethodsIn this study, we tried to uncover possible effect by correlating peritumoral DR in a necroinflammatory microenvironment with postoperative prognosis in HCC. The expression of peritumoral DR-CK19 by immunohistochemistry, necroinflammation and fibrosis were assessed from 106 patients receiving curative resection for HCC. Prognostic values for these and other clinicopathologic factors were evaluated.

ResultsPeritumoral DR significantly correlated with necroinflammation r = 0.563, p = 3.4E-10, fibrosis r = 0.435, p = 3.1E-06, AFP level p = 0.010, HBsAg p = 4.9E-4, BCLC stage p = 0.003, TNM stage p = 0.002, multiple nodules p = 0.004, absence of tumor capsule p = 0.027, severe microscopic vascular invasion p = 0.031 and early recurrence p = 0.010. Increased DR was significantly associated with decreased RFS-OS p = 4.8E-04 and p = 2.6E-05, respectively in univariate analysis and were identified as an independent prognostic factor HR = 2.380, 95% CI = 1.250-4.534, p = 0.008 for RFS; HR = 4.294, 95% CI = 2.255-8.177, p = 9.3E-6 for OS in multivariate analysis.

ConclusionsThese results suggested that peritumoral DR in a necroinflammatory microenvironment was a poor prognostic factor for HCC after resection.

KeywordsDuctular reaction DR Hepatic progenitor cells HPCs Necroinflammation Fibrosis Hepatocellular carcinoma HCC Prognosis AbbreviationsAFPAlpha fetoprotein

BCLC stageBarcelona-Clinic Liver Cancer stage

CCl4Chronic carbon tetrachloride

DRDuctular reaction

EMTEpithelial-mesenchymal transition

HCCHepatocellular carcinoma

HCVHepatitis C virus

HPCsHepatic progenitor cells

OSOverall survival time

RFSRecurrence-free survival time.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2407-14-65 contains supplementary material, which is available to authorized users.

Minhui Xu, Feng Xie contributed equally to this work.

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Autor: Minhui Xu - Feng Xie - Guangyang Qian - Yingying Jing - Shanshan Zhang - Lu Gao - Tao Zheng - Mengchao Wu - Jiamei Yang -


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