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BMC Medicine

, 12:32

Spotlight on breast cancer

Abstract

The ovarian steroid hormone, progesterone, and its nuclear receptor, the progesterone receptor, are implicated in the progression of breast cancer. Clinical trial data on the effects of hormone replacement therapy underscore the importance of understanding how progestins influence breast cancer growth. The progesterone receptor regulation of distinct target genes is mediated by complex interactions between the progesterone receptor and other regulatory factors that determine the context-dependent transcriptional action of the progesterone receptor. These interactions often lead to post-translational modifications to the progesterone receptor that can dramatically alter receptor function, both in the normal mammary gland and in breast cancer. This review highlights the molecular components that regulate progesterone receptor transcriptional action and describes how a better understanding of the complex interactions between the progesterone receptor and other regulatory factors may be critical to enhancing the clinical efficacy of anti-progestins for use in the treatment of breast cancer.

KeywordsBreast cancer Post-translational modifications Progesterone receptor Signal transduction AbbreviationsARandrogen receptor

ERestrogen receptor

GRglucocorticoid receptor

HRThormone-replacement therapy

PRprogesterone receptor

SRsteroid receptor.

Electronic supplementary materialThe online version of this article doi:10.1186-1741-7015-12-32 contains supplementary material, which is available to authorized users.

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Autor: Christy R Hagan - Carol A Lange

Fuente: https://link.springer.com/



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