Activation of protease-activated receptor 2 reduces glioblastoma cell apoptosisReportar como inadecuado

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Journal of Biomedical Science

, 21:25

First Online: 26 March 2014Received: 29 August 2013Accepted: 19 March 2014DOI: 10.1186-1423-0127-21-25

Cite this article as: Luo, R., Wang, X., Dong, Y. et al. J Biomed Sci 2014 21: 25. doi:10.1186-1423-0127-21-25


BackgroundThe pathogenesis of glioma is unclear. The disturbance of the apoptosis process plays a critical role in glioma growth. Factors regulating the apoptosis process are to be further understood. This study aims to investigate the role of protease activated receptor-2 PAR2 in regulation the apoptosis process in glioma cells.

ResultsThe results showed that U87 cells and human glioma tissue expressed PAR2. Exposure to tryptase, or the PAR2 active peptide, increased STAT3 phosphorylation in the radiated U87 cells, reduced U87 cell apoptosis, suppressed the expression of p53 in U87 cells.

ConclusionsActivation of PAR2 can reduce the radiated U87 cell apoptosis via modulating the expression of p53. The results implicate that PAR2 may be a novel therapeutic target in the treatment of glioma.

KeywordsGlioma Tryptase Protease-activated receptor 2 Signal transducer and activator of transcription 3 p53 Electronic supplementary materialThe online version of this article doi:10.1186-1423-0127-21-25 contains supplementary material, which is available to authorized users.

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Autor: Ran Luo - Xiongwei Wang - Yuanxun Dong - Lei Wang - Chunlei Tian


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