Serum interleukin-6 level as an early marker of injury severity in trauma patients in an urban low-income setting: a cross-sectional studyReport as inadecuate




Serum interleukin-6 level as an early marker of injury severity in trauma patients in an urban low-income setting: a cross-sectional study - Download this document for free, or read online. Document in PDF available to download.

BMC Emergency Medicine

, 15:22

First Online: 16 September 2015Received: 13 December 2014Accepted: 10 September 2015DOI: 10.1186-s12873-015-0048-z

Cite this article as: Okeny, P.K., Ongom, P. & Kituuka, O. BMC Emerg Med 2015 15: 22. doi:10.1186-s12873-015-0048-z

Abstract

BackgroundTrauma is still the leading cause of death in many regions of the world. Severity scores have been developed to assist in management of trauma victims. Immune response to trauma has been known to positively correspond to the severity of trauma. Part of this response involves release of cytokines into blood circulation which promote the acute inflammatory response commonly seen after trauma. Studies have shown that IL-6 levels commonly correlate positively with the Injury Severity Score ISS. The aim of this cross-sectional study was to determine whether this kind of relationship exists between IL-6 levels and injury severity in trauma patients in Mulago Hospital as defined by the Kampala Trauma Score KTSII which is locally developed.

MethodsTrauma patients aged ≥18 years presenting to the Accident and Emergency unit of Mulago National Referral Hospital MNRH within 12 h after injury were recruited into the study after obtaining consent. Severity of injury was determined as per the Kampala Trauma Score KTSII and venous blood drawn for assay of serum IL-6 levels. Data obtained was entered and analyzed using Stata version 11 software focusing on the association between Serum IL-6 levels with Severity of trauma and duration of injury.

ResultsA total of 159 patients were recruited 79 Mild and 80 Severe trauma with a male to female ratio of 4.7:1. Road traffic crashes 67.92 % were the commonest cause of injury. Serum IL-6 levels were found to positively correspond with severity of injury z = 4.718, p < 0.001. There was no significant correlation between serum IL-6 levels and duration of injury in both severe r = 0.12, p = 0.29 and mild r = 0.06, p = 0.62 trauma groups of patients. Only 9.43 % of trauma patients were brought in an Ambulance.

ConclusionsSerum IL-6 levels correspond with severity of injury. However, within the first twelve hours after injury, these levels did not vary significantly with duration of injury.

KeywordsInterleukin-6 Kampala Trauma Score II Duration of injury AbbreviationsISSInjury Severity Score

RTSRevised Trauma Score

TRISSTrauma Injury Severity Score

KTSIIKampala Trauma Score two

MNRHMulago National Referral Hospital

IL-6Interleukin-6

DAMPsDamage associated molecular patterns

ATLSAdvanced Trauma Life Support

AandEAccident and Emergency

Peter Ongom Deceased

Download fulltext PDF



Author: Paul K. Okeny - Peter Ongom - Olivia Kituuka

Source: https://link.springer.com/







Related documents