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BMC Proceedings

, 3:S7

First Online: 16 July 2009DOI: 10.1186-1753-6561-3-S4-S7

Cite this article as: Prickett, D. & Watson, M. BMC Proc 2009 3Suppl 4: S7. doi:10.1186-1753-6561-3-S4-S7

Abstract

BackgroundMicroarrays allow genome-wide assays of gene expression. There is a need for user-friendly software to visualise and analyse these data. Analysing microarray data in the context of biological pathways is now common, and several tools exist.

ResultsWe describe the use of MAPPFinder, a component of GenMAPP to characterise the biological pathways affected in chickens infected with the protozoan parasite Eimeria. Several pathways were significantly affected based on the unadjusted p-value, including several immune-system pathways.

ConclusionGenMAPP-MAPPFinder provides a means to rapidly visualise pathways affected in microarray studies. However, it relies on good genome annotation and having genes reliably linked to pathway objects. We show that GenMAPP-MAPPFinder can produce useful results, and as the annotation of the chicken genome improves, so will the level of information gained.

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Autor: Dennis Prickett - Michael Watson

Fuente: https://link.springer.com/







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